The endogenous cellular protease inhibitor SPINT2 controls SARS-CoV-2 viral infection and is associated to disease severity

• Carlos Ramirez Alvarez ,

  Contributed equally to this work with: Carlos Ramirez Alvarez, Carmon Kee

  Roles Conceptualization, Formal analysis, Methodology, Writing – original draft

  Affiliation Health Data Science Unit, Medical Faculty Heidelberg and BioQuant, Heidelberg, Germany

  https://orcid.org/0000-0002-7335-8447

  ⨯
• Carmon Kee ,

  Contributed equally to this work with: Carlos Ramirez Alvarez, Carmon Kee

  Roles Investigation, Methodology

  Affiliations Department of Infectious Diseases, Virology, Heidelberg University, Heidelberg, Germany, Research Group “Cellular Polarity and Viral Infection”, German Cancer Research Center (DKFZ), Heidelberg, Germany

  https://orcid.org/0000-0001-5847-5509

  ⨯
• Ashwini Kumar Sharma,

  Roles Formal analysis, Visualization

  Affiliation Health Data Science Unit, Medical Faculty Heidelberg and BioQuant, Heidelberg, Germany

  ⨯
• Leonie Thomas,

  Roles Formal analysis

  Affiliation Health Data Science Unit, Medical Faculty Heidelberg and BioQuant, Heidelberg, Germany

  https://orcid.org/0000-0002-3249-4338

  ⨯
• Florian I. Schmidt,

  Roles Methodology, Validation

  Affiliation Institute of Innate Immunity, Medical Faculty, University of Bonn, Bonn, Germany

  ⨯
• Megan L. Stanifer,

  Roles Investigation, Methodology

  Affiliation Department of Infectious Diseases, Molecular Virology, Heidelberg University, Heidelberg, Germany

  ⨯
• Steeve Boulant ,

  Roles Project administration, Supervision

  * E-mail: steeve.boulant@med.uni-heidelberg.de (SB); carl.herrmann@bioquant.uni-heidelberg.de (CH)

  Affiliations Department of Infectious Diseases, Virology, Heidelberg University, Heidelberg, Germany, Research Group “Cellular Polarity and Viral Infection”, German Cancer Research Center (DKFZ), Heidelberg, Germany

  ⨯
• Carl Herrmann

  Roles Conceptualization, Methodology, Project administration, Supervision, Writing – original draft

  * E-mail: steeve.boulant@med.uni-heidelberg.de (SB); carl.herrmann@bioquant.uni-heidelberg.de (CH)

  Affiliation Health Data Science Unit, Medical Faculty Heidelberg and BioQuant, Heidelberg, Germany

  https://orcid.org/0000-0003-4989-4722

  ⨯