Sustained viremia suppression by SHIVSF162P3CN-recalled effector-memory CD8+ T cells after PD1-based vaccination

Yik Chun Wong; Wan Liu; Lok Yan Yim; Xin Li; Hui Wang; Ming Yue; Mengyue Niu; Lin Cheng; Lijun Ling; Yanhua Du; Samantha M. Y. Chen; Ka-Wai Cheung; Haibo Wang; Xian Tang; Jiansong Tang; Haoji Zhang; Youqiang Song; Lisa A. Chakrabarti; Zhiwei Chen

doi:10.1371/journal.ppat.1009647

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Open Access

Peer-reviewed

Research Article

Sustained viremia suppression by SHIV_SF162P3CN-recalled effector-memory CD8⁺ T cells after PD1-based vaccination

Yik Chun Wong ,

Contributed equally to this work with: Yik Chun Wong, Wan Liu, Lok Yan Yim, Xin Li, Hui Wang, Ming Yue

Roles Formal analysis, Investigation, Methodology, Writing – original draft

Affiliations AIDS Institute, Department of Microbiology, State Key Laboratory of Emerging Infectious Diseases, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong SAR, China, HKU-AIDS Institute Shenzhen Research Laboratory and AIDS Clinical Research Laboratory, Guangdong Key Laboratory of Emerging Infectious Diseases, Shenzhen Key Laboratory of Infection and Immunity, Shenzhen Third People’s Hospital, Shenzhen, China
⨯
Wan Liu ,

Contributed equally to this work with: Yik Chun Wong, Wan Liu, Lok Yan Yim, Xin Li, Hui Wang, Ming Yue

Roles Formal analysis, Investigation, Methodology

Affiliation AIDS Institute, Department of Microbiology, State Key Laboratory of Emerging Infectious Diseases, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong SAR, China
⨯
Lok Yan Yim ,

Contributed equally to this work with: Yik Chun Wong, Wan Liu, Lok Yan Yim, Xin Li, Hui Wang, Ming Yue

Roles Formal analysis, Investigation, Writing – original draft

Affiliations AIDS Institute, Department of Microbiology, State Key Laboratory of Emerging Infectious Diseases, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong SAR, China, HKU-AIDS Institute Shenzhen Research Laboratory and AIDS Clinical Research Laboratory, Guangdong Key Laboratory of Emerging Infectious Diseases, Shenzhen Key Laboratory of Infection and Immunity, Shenzhen Third People’s Hospital, Shenzhen, China

https://orcid.org/0000-0001-7971-4011

⨯
Xin Li ,

Contributed equally to this work with: Yik Chun Wong, Wan Liu, Lok Yan Yim, Xin Li, Hui Wang, Ming Yue

Roles Formal analysis, Investigation

Affiliations AIDS Institute, Department of Microbiology, State Key Laboratory of Emerging Infectious Diseases, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong SAR, China, Department of Veterinary Medicine, Foshan University, Foshan, China
⨯
Hui Wang ,

Contributed equally to this work with: Yik Chun Wong, Wan Liu, Lok Yan Yim, Xin Li, Hui Wang, Ming Yue

Roles Formal analysis, Investigation

Affiliation HKU-AIDS Institute Shenzhen Research Laboratory and AIDS Clinical Research Laboratory, Guangdong Key Laboratory of Emerging Infectious Diseases, Shenzhen Key Laboratory of Infection and Immunity, Shenzhen Third People’s Hospital, Shenzhen, China
⨯
Ming Yue ,

Contributed equally to this work with: Yik Chun Wong, Wan Liu, Lok Yan Yim, Xin Li, Hui Wang, Ming Yue

Roles Formal analysis, Investigation

Affiliation School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong SAR, China
⨯
Mengyue Niu,

Roles Formal analysis, Investigation

Affiliation AIDS Institute, Department of Microbiology, State Key Laboratory of Emerging Infectious Diseases, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong SAR, China
⨯
Lin Cheng,

Roles Formal analysis, Investigation

Affiliation HKU-AIDS Institute Shenzhen Research Laboratory and AIDS Clinical Research Laboratory, Guangdong Key Laboratory of Emerging Infectious Diseases, Shenzhen Key Laboratory of Infection and Immunity, Shenzhen Third People’s Hospital, Shenzhen, China
⨯
Lijun Ling,

Roles Investigation

Affiliation AIDS Institute, Department of Microbiology, State Key Laboratory of Emerging Infectious Diseases, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong SAR, China
⨯
Yanhua Du,

Roles Investigation

Affiliation AIDS Institute, Department of Microbiology, State Key Laboratory of Emerging Infectious Diseases, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong SAR, China
⨯
Samantha M. Y. Chen,

Roles Formal analysis, Investigation

Affiliation AIDS Institute, Department of Microbiology, State Key Laboratory of Emerging Infectious Diseases, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong SAR, China

https://orcid.org/0000-0002-7876-4428

⨯
Ka-Wai Cheung,

Roles Resources

Affiliation AIDS Institute, Department of Microbiology, State Key Laboratory of Emerging Infectious Diseases, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong SAR, China
⨯
Haibo Wang,

Roles Formal analysis, Investigation

Affiliation AIDS Institute, Department of Microbiology, State Key Laboratory of Emerging Infectious Diseases, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong SAR, China
⨯
Xian Tang,

Roles Formal analysis, Investigation

Affiliations HKU-AIDS Institute Shenzhen Research Laboratory and AIDS Clinical Research Laboratory, Guangdong Key Laboratory of Emerging Infectious Diseases, Shenzhen Key Laboratory of Infection and Immunity, Shenzhen Third People’s Hospital, Shenzhen, China, Virus and Immunity Unit, Pasteur Institute, Paris, France; INSERM U1108, Paris, France
⨯
Jiansong Tang,

Roles Investigation

Affiliation AIDS Institute, Department of Microbiology, State Key Laboratory of Emerging Infectious Diseases, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong SAR, China
⨯
Haoji Zhang,

Roles Formal analysis, Investigation

Affiliation Department of Veterinary Medicine, Foshan University, Foshan, China
⨯
Youqiang Song,

Roles Formal analysis, Investigation

Affiliation School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong SAR, China

https://orcid.org/0000-0001-9407-2256

⨯
Lisa A. Chakrabarti,

Roles Formal analysis, Investigation, Writing – review & editing

Affiliation Virus and Immunity Unit, Pasteur Institute, Paris, France; INSERM U1108, Paris, France

https://orcid.org/0000-0002-1895-3630

⨯
[ ... ],
Zhiwei Chen

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Writing – original draft, Writing – review & editing

* E-mail: zchenai@hku.hk

Affiliations AIDS Institute, Department of Microbiology, State Key Laboratory of Emerging Infectious Diseases, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong SAR, China, HKU-AIDS Institute Shenzhen Research Laboratory and AIDS Clinical Research Laboratory, Guangdong Key Laboratory of Emerging Infectious Diseases, Shenzhen Key Laboratory of Infection and Immunity, Shenzhen Third People’s Hospital, Shenzhen, China
⨯
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Sustained viremia suppression by SHIV_SF162P3CN-recalled effector-memory CD8⁺ T cells after PD1-based vaccination

Yik Chun Wong,
Wan Liu,
Lok Yan Yim,
Xin Li,
Hui Wang,
Ming Yue,
Mengyue Niu,
Lin Cheng,
Lijun Ling,
Yanhua Du

Published: June 14, 2021
https://doi.org/10.1371/journal.ppat.1009647

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