Structurally distinct external solvent-exposed domains drive replication of major human prions

• Mohammad Khursheed Siddiqi,

  Roles Conceptualization, Data curation, Formal analysis, Writing – original draft

  Affiliation Department of Pathology, Case Western Reserve University, Cleveland, Ohio, United States of America

  https://orcid.org/0000-0002-6522-1643

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• Chae Kim,

  Roles Conceptualization, Data curation, Formal analysis

  Affiliation Department of Pathology, Case Western Reserve University, Cleveland, Ohio, United States of America

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• Tracy Haldiman,

  Roles Conceptualization, Data curation, Formal analysis

  Affiliation Department of Pathology, Case Western Reserve University, Cleveland, Ohio, United States of America

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• Miroslava Kacirova,

  Roles Conceptualization, Data curation, Methodology

  Current address: Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Prague, Czech Republic

  Affiliation Department of Pathology, Case Western Reserve University, Cleveland, Ohio, United States of America

  https://orcid.org/0000-0002-1478-1712

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• Benlian Wang,

  Roles Data curation, Methodology

  Affiliations Department of Nutrition, Case Western Reserve University, Cleveland, Ohio, United States of America, Center for Proteomics and Bioinformatics, Case Center for Synchrotron Biosciences, Brookhaven National Laboratory, Upton, New York, United States of America

  https://orcid.org/0000-0002-6108-0417

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• Jen Bohon,

  Roles Data curation, Formal analysis, Methodology

  Current address: Advanced Sources and Detectors Project Office, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America

  Affiliations Department of Nutrition, Case Western Reserve University, Cleveland, Ohio, United States of America, Center for Proteomics and Bioinformatics, Case Center for Synchrotron Biosciences, Brookhaven National Laboratory, Upton, New York, United States of America

  https://orcid.org/0000-0002-7664-9899

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• Mark R. Chance,

  Roles Conceptualization, Data curation, Formal analysis, Writing – review & editing

  Affiliations Department of Nutrition, Case Western Reserve University, Cleveland, Ohio, United States of America, Center for Proteomics and Bioinformatics, Case Center for Synchrotron Biosciences, Brookhaven National Laboratory, Upton, New York, United States of America

  https://orcid.org/0000-0002-2991-6405

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• Janna Kiselar,

  Roles Conceptualization, Data curation, Formal analysis, Methodology, Writing – original draft, Writing – review & editing

  Affiliations Department of Nutrition, Case Western Reserve University, Cleveland, Ohio, United States of America, Center for Proteomics and Bioinformatics, Case Center for Synchrotron Biosciences, Brookhaven National Laboratory, Upton, New York, United States of America

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• Jiri G. Safar

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: jiri.safar@case.edu

  Affiliations Department of Pathology, Case Western Reserve University, Cleveland, Ohio, United States of America, Department of Neurology, Case Western Reserve University, Cleveland, Ohio, United States of America

  https://orcid.org/0000-0003-2209-0070

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