P300-mediated NEDD4 acetylation drives ebolavirus VP40 egress by enhancing NEDD4 ligase activity

Linliang Zhang; Shixiong Zhou; Majuan Chen; Jie Yan; Yi Yang; Linjuan Wu; Dongning Jin; Lei Yin; Mingzhou Chen; Yali Qin

doi:10.1371/journal.ppat.1009616

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Open Access

Peer-reviewed

Research Article

P300-mediated NEDD4 acetylation drives ebolavirus VP40 egress by enhancing NEDD4 ligase activity

Linliang Zhang,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

Affiliation State Key Laboratory of Virology and Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan, China
⨯
Shixiong Zhou,

Roles Data curation, Investigation

Affiliation State Key Laboratory of Virology and Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan, China
⨯
Majuan Chen,

Roles Investigation

Affiliation State Key Laboratory of Virology and Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan, China
⨯
Jie Yan,

Roles Investigation

Affiliation State Key Laboratory of Virology and Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan, China
⨯
Yi Yang,

Roles Validation

Affiliation State Key Laboratory of Virology and Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan, China
⨯
Linjuan Wu,

Roles Methodology

Affiliation State Key Laboratory of Virology and Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan, China
⨯
Dongning Jin,

Roles Methodology

Affiliation State Key Laboratory of Virology and Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan, China
⨯
Lei Yin,

Roles Validation

Affiliation State Key Laboratory of Virology and Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan, China

https://orcid.org/0000-0001-5203-2766

⨯
Mingzhou Chen ,

Roles Funding acquisition, Project administration, Supervision, Writing – review & editing

* E-mail: chenmz@whu.edu.cn(MC); yqin@whu.edu.cn(YQ)

Affiliation State Key Laboratory of Virology and Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan, China

https://orcid.org/0000-0001-5308-6897

⨯
Yali Qin

Roles Conceptualization, Supervision

* E-mail: chenmz@whu.edu.cn(MC); yqin@whu.edu.cn(YQ)

Affiliation State Key Laboratory of Virology and Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan, China
⨯

P300-mediated NEDD4 acetylation drives ebolavirus VP40 egress by enhancing NEDD4 ligase activity

Linliang Zhang,
Shixiong Zhou,
Majuan Chen,
Jie Yan,
Yi Yang,
Linjuan Wu,
Dongning Jin,
Lei Yin,
Mingzhou Chen,
Yali Qin

Published: June 10, 2021
https://doi.org/10.1371/journal.ppat.1009616

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Acetylation
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Ebola virus
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Ubiquitination
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Immunoprecipitation
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Transfection
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Immunoblotting
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Cell membranes
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Ligases
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