Structures of Foot-and-mouth Disease Virus with neutralizing antibodies derived from recovered natural host reveal a mechanism for cross-serotype neutralization

• Yong He ,

  Contributed equally to this work with: Yong He, Kun Li

  Roles Conceptualization, Formal analysis, Investigation, Validation, Writing – original draft, Writing – review & editing

  Affiliations State Key Laboratory of Medicinal Chemical Biology and Drug Discovery Center for Infectious Disease, College of Pharmacy, Nankai University, Tianjin, China, MOE Key Laboratory of Protein Science & Collaborative Innovation Center of Biotherapy, School of Medicine and School of Life Sciences, Tsinghua University, Beijing, China

  https://orcid.org/0000-0002-7460-2691

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• Kun Li ,

  Contributed equally to this work with: Yong He, Kun Li

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Validation, Writing – original draft, Writing – review & editing

  Affiliation State Key Laboratory of Veterinary Etiological Biology, National Foot-and-Mouth Diseases Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China

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• Yimei Cao,

  Roles Funding acquisition, Investigation

  Affiliation State Key Laboratory of Veterinary Etiological Biology, National Foot-and-Mouth Diseases Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China

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• Zixian Sun,

  Roles Formal analysis

  Affiliation MOE Key Laboratory of Protein Science & Collaborative Innovation Center of Biotherapy, School of Medicine and School of Life Sciences, Tsinghua University, Beijing, China

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• Pinghua Li,

  Roles Investigation

  Affiliation State Key Laboratory of Veterinary Etiological Biology, National Foot-and-Mouth Diseases Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China

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• Huifang Bao,

  Roles Investigation

  Affiliation State Key Laboratory of Veterinary Etiological Biology, National Foot-and-Mouth Diseases Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China

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• Sheng Wang,

  Roles Investigation

  Affiliation State Key Laboratory of Veterinary Etiological Biology, National Foot-and-Mouth Diseases Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China

  https://orcid.org/0000-0002-3079-4222

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• Guoqiang Zhu,

  Roles Investigation

  Affiliation State Key Laboratory of Veterinary Etiological Biology, National Foot-and-Mouth Diseases Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China

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• Xingwen Bai,

  Roles Investigation

  Affiliation State Key Laboratory of Veterinary Etiological Biology, National Foot-and-Mouth Diseases Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China

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• Pu Sun,

  Roles Investigation

  Affiliation State Key Laboratory of Veterinary Etiological Biology, National Foot-and-Mouth Diseases Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China

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• Xuerong Liu,

  Roles Resources

  Affiliation China Agricultural Vet Biology and Technology Co. Ltd., Lanzhou, China

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• Cheng Yang,

  Roles Supervision

  Affiliation State Key Laboratory of Medicinal Chemical Biology and Drug Discovery Center for Infectious Disease, College of Pharmacy, Nankai University, Tianjin, China

  https://orcid.org/0000-0001-9431-290X

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• Zaixin Liu ,

  Roles Funding acquisition

  * E-mail: liuzaixin@caas.cn (ZL); luzengjun@caas.cn (ZL); raozh@tsinghua.edu.cn (ZR); louzy@mail.tsinghua.edu.cn (ZL)

  Affiliation State Key Laboratory of Veterinary Etiological Biology, National Foot-and-Mouth Diseases Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China

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• Zengjun Lu ,

  Roles Conceptualization, Supervision

  * E-mail: liuzaixin@caas.cn (ZL); luzengjun@caas.cn (ZL); raozh@tsinghua.edu.cn (ZR); louzy@mail.tsinghua.edu.cn (ZL)

  Affiliation State Key Laboratory of Veterinary Etiological Biology, National Foot-and-Mouth Diseases Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China

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• Zihe Rao ,

  Roles Funding acquisition, Supervision, Writing – original draft

  * E-mail: liuzaixin@caas.cn (ZL); luzengjun@caas.cn (ZL); raozh@tsinghua.edu.cn (ZR); louzy@mail.tsinghua.edu.cn (ZL)

  Affiliations State Key Laboratory of Medicinal Chemical Biology and Drug Discovery Center for Infectious Disease, College of Pharmacy, Nankai University, Tianjin, China, MOE Key Laboratory of Protein Science & Collaborative Innovation Center of Biotherapy, School of Medicine and School of Life Sciences, Tsinghua University, Beijing, China

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•  [ ... ],
• Zhiyong Lou

  Roles Conceptualization, Funding acquisition, Supervision, Validation, Writing – original draft, Writing – review & editing

  * E-mail: liuzaixin@caas.cn (ZL); luzengjun@caas.cn (ZL); raozh@tsinghua.edu.cn (ZR); louzy@mail.tsinghua.edu.cn (ZL)

  Affiliation MOE Key Laboratory of Protein Science & Collaborative Innovation Center of Biotherapy, School of Medicine and School of Life Sciences, Tsinghua University, Beijing, China

  https://orcid.org/0000-0003-2728-881X

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