Deconvolution of intergenic polymorphisms determining high expression of Factor H binding protein in meningococcus and their association with invasive disease

Marco Spinsanti; Tarcisio Brignoli; Margherita Bodini; Lucia Eleonora Fontana; Matteo De Chiara; Alessia Biolchi; Alessandro Muzzi; Vincenzo Scarlato; Isabel Delany

doi:10.1371/journal.ppat.1009461

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Open Access

Peer-reviewed

Research Article

Deconvolution of intergenic polymorphisms determining high expression of Factor H binding protein in meningococcus and their association with invasive disease

Marco Spinsanti,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation GSK, Siena, Italy

https://orcid.org/0000-0002-5098-3901

⨯
Tarcisio Brignoli,

Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – review & editing

Current address: School of Cellular and Molecular Medicine, University of Bristol, Bristol, United Kingdom

Affiliations GSK, Siena, Italy, Department of Pharmacy and Biotechnology (FaBiT), University of Bologna, Bologna, Italy

https://orcid.org/0000-0003-4601-4080

⨯
Margherita Bodini,

Roles Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Writing – review & editing

Affiliation GSK, Siena, Italy

https://orcid.org/0000-0002-7054-8712

⨯
Lucia Eleonora Fontana,

Roles Investigation, Methodology, Validation, Writing – review & editing

Affiliation GSK, Siena, Italy

https://orcid.org/0000-0002-1871-1084

⨯
Matteo De Chiara,

Roles Formal analysis, Investigation, Methodology, Writing – review & editing

Current address: Université Côte d’Azur, CNRS, INSERM, IRCAN, Nice, France

Affiliation GSK, Siena, Italy

https://orcid.org/0000-0003-1014-350X

⨯
Alessia Biolchi,

Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – review & editing

Affiliation GSK, Siena, Italy
⨯
Alessandro Muzzi,

Roles Formal analysis, Investigation, Software, Supervision, Writing – review & editing

Affiliation GSK, Siena, Italy

https://orcid.org/0000-0002-8635-6424

⨯
Vincenzo Scarlato,

Roles Conceptualization, Investigation, Supervision, Writing – review & editing

Affiliation Department of Pharmacy and Biotechnology (FaBiT), University of Bologna, Bologna, Italy

https://orcid.org/0000-0003-4227-677X

⨯
Isabel Delany

Roles Conceptualization, Funding acquisition, Investigation, Supervision, Writing – original draft, Writing – review & editing

* E-mail: isabel.x.delany@gsk.com

Affiliation GSK, Siena, Italy
⨯

Deconvolution of intergenic polymorphisms determining high expression of Factor H binding protein in meningococcus and their association with invasive disease

Marco Spinsanti,
Tarcisio Brignoli,
Margherita Bodini,
Lucia Eleonora Fontana,
Matteo De Chiara,
Alessia Biolchi,
Alessandro Muzzi,
Vincenzo Scarlato,
Isabel Delany

Published: March 26, 2021
https://doi.org/10.1371/journal.ppat.1009461

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Neisseria meningitidis
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Sequence alignment
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