Disruption of the Pseudomonas aeruginosa Tat system perturbs PQS-dependent quorum sensing and biofilm maturation through lack of the Rieske cytochrome bc1 sub-unit

Eliza Ye-Chen Soh; Frances Smith; Maxime Rémi Gimenez; Liang Yang; Rebecca Munk Vejborg; Matthew Fletcher; Nigel Halliday; Sophie Bleves; Stephan Heeb; Miguel Cámara; Michael Givskov; Kim R. Hardie; Tim Tolker-Nielsen; Bérengère Ize; Paul Williams

doi:10.1371/journal.ppat.1009425

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Open Access

Peer-reviewed

Research Article

Disruption of the Pseudomonas aeruginosa Tat system perturbs PQS-dependent quorum sensing and biofilm maturation through lack of the Rieske cytochrome bc₁ sub-unit

Eliza Ye-Chen Soh ,

Roles Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

¶‡ These authors share first authorship on this work.

Affiliation Biodiscovery Institute, National Biofilms Innovation Centre and School of Life Sciences, University of Nottingham, Nottingham, United Kingdom
⨯
Frances Smith ,

Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – review & editing

¶‡ These authors share first authorship on this work.

Affiliation Biodiscovery Institute, National Biofilms Innovation Centre and School of Life Sciences, University of Nottingham, Nottingham, United Kingdom

https://orcid.org/0000-0001-7203-3037

⨯
Maxime Rémi Gimenez,

Roles Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

Affiliation Laboratoire d’Ingénierie des Systèmes Macromoléculaires (LISM-UMR7255), Institut de Microbiologie de la Méditerranée, CNRS and Aix-Marseille University, Marseille, France

https://orcid.org/0000-0002-6991-3479

⨯
Liang Yang,

Roles Conceptualization, Formal analysis, Investigation, Writing – review & editing

Current Address: School of Medicine, Southern University of Science and Technology, Guangdong, China

Affiliation Singapore Centre for Environmental Life Sciences Engineering, Nanyang Technological University, Singapore

https://orcid.org/0000-0002-2362-0128

⨯
Rebecca Munk Vejborg,

Roles Data curation, Formal analysis, Investigation, Writing – review & editing

Affiliation Costerton Biofilm Center, Department of Immunology and Microbiology, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark

https://orcid.org/0000-0003-0365-1100

⨯
Matthew Fletcher,

Roles Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

Affiliation Biodiscovery Institute, National Biofilms Innovation Centre and School of Life Sciences, University of Nottingham, Nottingham, United Kingdom
⨯
Nigel Halliday,

Roles Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

Affiliation Biodiscovery Institute, National Biofilms Innovation Centre and School of Life Sciences, University of Nottingham, Nottingham, United Kingdom
⨯
Sophie Bleves,

Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Writing – review & editing

Affiliation Laboratoire d’Ingénierie des Systèmes Macromoléculaires (LISM-UMR7255), Institut de Microbiologie de la Méditerranée, CNRS and Aix-Marseille University, Marseille, France

https://orcid.org/0000-0002-9406-3437

⨯
Stephan Heeb,

Roles Formal analysis, Supervision, Visualization, Writing – review & editing

Affiliation Biodiscovery Institute, National Biofilms Innovation Centre and School of Life Sciences, University of Nottingham, Nottingham, United Kingdom

https://orcid.org/0000-0002-5079-3622

⨯
Miguel Cámara,

Roles Conceptualization, Writing – review & editing

Affiliation Biodiscovery Institute, National Biofilms Innovation Centre and School of Life Sciences, University of Nottingham, Nottingham, United Kingdom

https://orcid.org/0000-0003-4585-7385

⨯
Michael Givskov,

Roles Conceptualization, Funding acquisition, Project administration, Writing – review & editing

Affiliations Singapore Centre for Environmental Life Sciences Engineering, Nanyang Technological University, Singapore, Costerton Biofilm Center, Department of Immunology and Microbiology, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
⨯
Kim R. Hardie,

Roles Conceptualization, Supervision, Writing – review & editing

Affiliation Biodiscovery Institute, National Biofilms Innovation Centre and School of Life Sciences, University of Nottingham, Nottingham, United Kingdom

https://orcid.org/0000-0002-4892-2739

⨯
Tim Tolker-Nielsen ,

Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Supervision, Writing – review & editing

* E-mail: ttn@sund.ku.dk (TT-N); bize@imm.cnrs.fr (BI); paul.williams@nottingham.ac.uk (PW)

Affiliation Costerton Biofilm Center, Department of Immunology and Microbiology, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark

https://orcid.org/0000-0002-9751-474X

⨯
Bérengère Ize ,

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Project administration, Supervision, Writing – review & editing

* E-mail: ttn@sund.ku.dk (TT-N); bize@imm.cnrs.fr (BI); paul.williams@nottingham.ac.uk (PW)

Affiliation Laboratoire d’Ingénierie des Systèmes Macromoléculaires (LISM-UMR7255), Institut de Microbiologie de la Méditerranée, CNRS and Aix-Marseille University, Marseille, France

https://orcid.org/0000-0001-9106-9254

⨯
Paul Williams

Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Supervision, Writing – original draft

* E-mail: ttn@sund.ku.dk (TT-N); bize@imm.cnrs.fr (BI); paul.williams@nottingham.ac.uk (PW)

Affiliation Biodiscovery Institute, National Biofilms Innovation Centre and School of Life Sciences, University of Nottingham, Nottingham, United Kingdom

https://orcid.org/0000-0002-1920-5036

⨯

Disruption of the Pseudomonas aeruginosa Tat system perturbs PQS-dependent quorum sensing and biofilm maturation through lack of the Rieske cytochrome bc₁ sub-unit

Eliza Ye-Chen Soh,
Frances Smith,
Maxime Rémi Gimenez,
Liang Yang,
Rebecca Munk Vejborg,
Matthew Fletcher,
Nigel Halliday,
Sophie Bleves,
Stephan Heeb,
Miguel Cámara

Published: August 30, 2021
https://doi.org/10.1371/journal.ppat.1009425

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