Genomics of an endemic cystic fibrosis Burkholderia multivorans strain reveals low within-patient evolution but high between-patient diversity

• Cédric Lood ,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Software, Visualization, Writing – original draft, Writing – review & editing

  ¶‡ These authors are joint first authors on this work.

  Affiliations Department of Biosystems, Laboratory of Gene Technology, KU Leuven, Leuven, Belgium, Department of Microbial and Molecular Systems, Centre of Microbial and Plant Genetics, Laboratory of Computational Systems Biology, KU Leuven, Leuven, Belgium

  https://orcid.org/0000-0001-7826-3378

  ⨯
• Charlotte Peeters ,

  Roles Conceptualization, Data curation, Investigation, Methodology, Project administration, Writing – original draft, Writing – review & editing

  ¶‡ These authors are joint first authors on this work.

  Affiliation Belgian National Reference Centre for Burkholderia, Laboratory of Microbiology, Department of Biochemistry and Microbiology, Faculty of Sciences, Ghent University, Ghent, Belgium

  https://orcid.org/0000-0002-1891-4869

  ⨯
• Quentin Lamy-Besnier,

  Roles Data curation, Investigation, Writing – review & editing

  Affiliation Department of Biosystems, Laboratory of Gene Technology, KU Leuven, Leuven, Belgium

  https://orcid.org/0000-0002-7141-6340

  ⨯
• Jeroen Wagemans,

  Roles Investigation, Supervision, Writing – review & editing

  Affiliation Department of Biosystems, Laboratory of Gene Technology, KU Leuven, Leuven, Belgium

  https://orcid.org/0000-0002-2185-5724

  ⨯
• Daniel De Vos,

  Roles Investigation, Resources, Supervision, Writing – review & editing

  Affiliation Laboratory for Molecular and Cellular Technology (LabMCT), Queen Astrid Military Hospital, Brussels, Belgium

  https://orcid.org/0000-0001-9193-7410

  ⨯
• Marijke Proesmans,

  Roles Investigation, Resources, Writing – review & editing

  Affiliation Department of Pediatrics, University Hospital Leuven, University of Leuven, Leuven, Belgium

  https://orcid.org/0000-0002-5576-9517

  ⨯
• Jean-Paul Pirnay,

  Roles Investigation, Resources, Supervision, Writing – review & editing

  Affiliation Laboratory for Molecular and Cellular Technology (LabMCT), Queen Astrid Military Hospital, Brussels, Belgium

  https://orcid.org/0000-0002-6863-5219

  ⨯
• Fedoua Echahidi,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliation Belgian National Reference Centre for Burkholderia, Department of Microbiology, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel (VUB), Brussels, Belgium

  https://orcid.org/0000-0001-8075-1012

  ⨯
• Denis Piérard,

  Roles Data curation, Investigation, Methodology, Resources, Supervision, Writing – review & editing

  Affiliation Belgian National Reference Centre for Burkholderia, Department of Microbiology, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel (VUB), Brussels, Belgium

  https://orcid.org/0000-0002-7756-3691

  ⨯
• Matthieu Thimmesch,

  Roles Investigation, Resources, Writing – review & editing

  Affiliation Department of Pediatric Pneumology, CHC MontLégia, Liège, Belgium

  https://orcid.org/0000-0001-6058-3373

  ⨯
• Anca Boeras,

  Roles Investigation, Resources, Writing – review & editing

  Affiliation Department of Microbiology, CHC MontLégia, Liège, Belgique

  https://orcid.org/0000-0002-7657-0187

  ⨯
• Katrien Lagrou,

  Roles Investigation, Resources, Writing – review & editing

  Affiliations Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium, Clinical department of Laboratory Medicine, University Hospital Leuven, Leuven, Belgium

  https://orcid.org/0000-0001-8668-1350

  ⨯
• Evelien De Canck,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliation Belgian National Reference Centre for Burkholderia, Laboratory of Microbiology, Department of Biochemistry and Microbiology, Faculty of Sciences, Ghent University, Ghent, Belgium

  ⨯
• Elke De Wachter,

  Roles Investigation, Resources, Writing – review & editing

  Affiliation Department of Pediatric Pulmonology, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel (VUB), Brussels, Belgium

  ⨯
• Vera van Noort,

  Roles Funding acquisition, Supervision, Writing – review & editing

  Affiliations Department of Microbial and Molecular Systems, Centre of Microbial and Plant Genetics, Laboratory of Computational Systems Biology, KU Leuven, Leuven, Belgium, Institute of Biology, Leiden University, Leiden, The Netherlands

  https://orcid.org/0000-0002-8436-6602

  ⨯
• Rob Lavigne ,

  Roles Conceptualization, Funding acquisition, Investigation, Resources, Supervision, Validation, Writing – review & editing

  * E-mail: rob.lavigne@kuleuven.be (RL); peter.vandamme@ugent.be (PV)

  Affiliation Department of Biosystems, Laboratory of Gene Technology, KU Leuven, Leuven, Belgium

  https://orcid.org/0000-0001-7377-1314

  ⨯
•  [ ... ],
• Peter Vandamme

  Roles Conceptualization, Funding acquisition, Investigation, Supervision, Validation, Writing – review & editing

  * E-mail: rob.lavigne@kuleuven.be (RL); peter.vandamme@ugent.be (PV)

  Affiliation Belgian National Reference Centre for Burkholderia, Laboratory of Microbiology, Department of Biochemistry and Microbiology, Faculty of Sciences, Ghent University, Ghent, Belgium

  https://orcid.org/0000-0002-5581-7937

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