A combined EM and proteomic analysis places HIV-1 Vpu at the crossroads of retromer and ESCRT complexes: PTPN23 is a Vpu-cofactor

• Charlotte A. Stoneham ,

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Resources, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: cstoneham@health.ucsd.edu (CAS); jguatelli@health.ucsd.edu (JG)

  Affiliation Department of Medicine, University of California, San Diego School of Medicine and Veterans Affairs San Diego Healthcare System, La Jolla, California, United States of America

  https://orcid.org/0000-0003-3729-6936

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• Simon Langer,

  Roles Formal analysis, Investigation, Validation, Writing – review & editing

  Affiliation Infectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California, United States of America

  https://orcid.org/0000-0002-9660-8058

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• Paul D. De Jesus,

  Roles Investigation, Writing – review & editing

  Current address: Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, United States of America

  Affiliation Infectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California, United States of America

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• Jacob M. Wozniak,

  Roles Data curation, Formal analysis, Investigation, Writing – review & editing

  Affiliation Department of Pharmacology, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California, United States of America

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• John Lapek,

  Roles Formal analysis, Investigation, Writing – review & editing

  Affiliation Department of Pharmacology, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California, United States of America

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• Thomas Deerinck,

  Roles Investigation, Writing – review & editing

  Affiliation National Center for Microscopy and Imaging Research, Center for Research on Biological Systems, University of California, San Diego, School of Medicine, La Jolla, California, United States of America

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• Andrea Thor,

  Roles Investigation, Writing – review & editing

  Affiliation National Center for Microscopy and Imaging Research, Center for Research on Biological Systems, University of California, San Diego, School of Medicine, La Jolla, California, United States of America

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• Lars Pache,

  Roles Funding acquisition, Resources, Writing – review & editing

  Affiliation Infectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California, United States of America

  https://orcid.org/0000-0002-4193-1042

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• Sumit K. Chanda,

  Roles Conceptualization, Funding acquisition, Resources, Supervision, Writing – review & editing

  Current address: Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, United States of America

  Affiliation Infectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California, United States of America

  https://orcid.org/0000-0001-9399-7927

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• David J. Gonzalez,

  Roles Conceptualization, Resources, Supervision, Writing – review & editing

  Affiliation Department of Pharmacology, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California, United States of America

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• Mark Ellisman,

  Roles Conceptualization, Resources, Supervision, Writing – review & editing

  Affiliations National Center for Microscopy and Imaging Research, Center for Research on Biological Systems, University of California, San Diego, School of Medicine, La Jolla, California, United States of America, Department of Neurosciences, University of California, San Diego School of Medicine, La Jolla, California, United States of America

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• John Guatelli

  Roles Conceptualization, Funding acquisition, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: cstoneham@health.ucsd.edu (CAS); jguatelli@health.ucsd.edu (JG)

  Affiliation Department of Medicine, University of California, San Diego School of Medicine and Veterans Affairs San Diego Healthcare System, La Jolla, California, United States of America

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