Deletion of a Golgi protein in Trypanosoma cruzi reveals a critical role for Mn2+ in protein glycosylation needed for host cell invasion and intracellular replication

Srinivasan Ramakrishnan; Linn M. Unger; Rodrigo P. Baptista; Teresa Cruz-Bustos; Roberto Docampo

doi:10.1371/journal.ppat.1009399

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Research Article

Deletion of a Golgi protein in Trypanosoma cruzi reveals a critical role for Mn²⁺ in protein glycosylation needed for host cell invasion and intracellular replication

Srinivasan Ramakrishnan ,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft

* E-mail: sri.ramakrishnan1984@gmail.com (SR); rdocampo@uga.edu (RD)

Current address: Department of Biology, Columbus State University, Columbus, Georgia, United States of America

Affiliation Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia, United States of America

https://orcid.org/0000-0001-8370-0528

⨯
Linn M. Unger,

Roles Investigation, Methodology

Affiliation Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia, United States of America
⨯
Rodrigo P. Baptista,

Roles Conceptualization, Data curation, Formal analysis, Methodology, Software

Affiliation Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia, United States of America

https://orcid.org/0000-0002-1806-8260

⨯
Teresa Cruz-Bustos,

Roles Conceptualization, Data curation, Formal analysis, Methodology

Current address: Institute of Parasitology, University of Veterinary Medicine, Vienna, Austria

Affiliation Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia, United States of America

https://orcid.org/0000-0002-6976-4354

⨯
Roberto Docampo

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Project administration, Resources, Supervision, Validation, Writing – review & editing

* E-mail: sri.ramakrishnan1984@gmail.com (SR); rdocampo@uga.edu (RD)

Affiliations Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia, United States of America, Department of Cellular Biology, University of Georgia, Athens, Georgia, United States of America

https://orcid.org/0000-0003-4229-8784

⨯

Deletion of a Golgi protein in Trypanosoma cruzi reveals a critical role for Mn²⁺ in protein glycosylation needed for host cell invasion and intracellular replication

Srinivasan Ramakrishnan,
Linn M. Unger,
Rodrigo P. Baptista,
Teresa Cruz-Bustos,
Roberto Docampo

Published: March 15, 2021
https://doi.org/10.1371/journal.ppat.1009399

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