Comparative analysis reveals the species-specific genetic determinants of ACE2 required for SARS-CoV-2 entry

• Wenlin Ren ,

  Contributed equally to this work with: Wenlin Ren, Yunkai Zhu, Yuyan Wang

  Roles Data curation, Formal analysis, Investigation, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Center for Infectious Disease Research, School of Medicine, Tsinghua University, Beijing, China

  https://orcid.org/0000-0002-7290-0935

  ⨯
• Yunkai Zhu ,

  Contributed equally to this work with: Wenlin Ren, Yunkai Zhu, Yuyan Wang

  Roles Investigation, Validation

  Affiliation Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Shanghai Medical College, Biosafety Level 3 Laboratory, Fudan University, Shanghai, China

  ⨯
• Yuyan Wang ,

  Contributed equally to this work with: Wenlin Ren, Yunkai Zhu, Yuyan Wang

  Roles Investigation

  Affiliation Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Shanghai Medical College, Biosafety Level 3 Laboratory, Fudan University, Shanghai, China

  ⨯
• Hongyang Shi,

  Roles Investigation

  Affiliations CAS Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China, University of Chinese Academy of Sciences, Beijing, China

  ⨯
• Yin Yu,

  Roles Investigation

  Affiliation Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Shanghai Medical College, Biosafety Level 3 Laboratory, Fudan University, Shanghai, China

  ⨯
• Gaowei Hu,

  Roles Investigation

  Affiliation Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Shanghai Medical College, Biosafety Level 3 Laboratory, Fudan University, Shanghai, China

  ⨯
• Fei Feng,

  Roles Investigation

  Affiliation Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Shanghai Medical College, Biosafety Level 3 Laboratory, Fudan University, Shanghai, China

  ⨯
• Xiaomin Zhao,

  Roles Data curation, Investigation

  Affiliation Center for Infectious Disease Research, School of Medicine, Tsinghua University, Beijing, China

  ⨯
• Jun Lan,

  Roles Investigation

  Affiliation School of Life Sciences, Tsinghua University, Beijing, China

  https://orcid.org/0000-0001-5550-2946

  ⨯
• Jianping Wu,

  Roles Investigation, Software

  Affiliations Zhejiang Provincial Laboratory of Life Sciences and Biomedicine, Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China, Institute of Biology, Westlake Institute for Advanced Study, Hangzhou, Zhejiang, China

  https://orcid.org/0000-0001-9869-7691

  ⨯
• Devin J. Kenney,

  Roles Methodology

  Affiliation Department of Microbiology, National Emerging Infectious Diseases Laboratories, Boston University School of Medicine, Boston, Massachusetts, United States of America

  https://orcid.org/0000-0002-8758-1930

  ⨯
• Florian Douam,

  Roles Methodology

  Affiliation Department of Microbiology, National Emerging Infectious Diseases Laboratories, Boston University School of Medicine, Boston, Massachusetts, United States of America

  https://orcid.org/0000-0002-4791-6767

  ⨯
• Yimin Tong,

  Roles Supervision

  Affiliation CAS Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China

  ⨯
• Jin Zhong,

  Roles Supervision, Writing – review & editing

  Affiliation CAS Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China

  https://orcid.org/0000-0002-3554-1275

  ⨯
• Youhua Xie,

  Roles Funding acquisition, Resources

  Affiliation Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Shanghai Medical College, Biosafety Level 3 Laboratory, Fudan University, Shanghai, China

  ⨯
• Xinquan Wang,

  Roles Resources

  Affiliations School of Life Sciences, Tsinghua University, Beijing, China, Beijing Advanced Innovation Center for Structural Biology, Tsinghua University, Beijing China

  https://orcid.org/0000-0003-3136-8070

  ⨯
• Zhenghong Yuan,

  Roles Resources

  Affiliation Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Shanghai Medical College, Biosafety Level 3 Laboratory, Fudan University, Shanghai, China

  ⨯
• Dongming Zhou,

  Roles Supervision

  Affiliation Department of Pathogen Biology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China

  https://orcid.org/0000-0002-5989-7591

  ⨯
• Rong Zhang ,

  Roles Conceptualization, Formal analysis, Funding acquisition, Methodology, Project administration, Software, Supervision, Validation, Writing – original draft, Writing – review & editing

  * E-mail: rong_zhang@fudan.edu.cn(RZ); qding@tsinghua.edu.cn(QD)

  Affiliation Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Shanghai Medical College, Biosafety Level 3 Laboratory, Fudan University, Shanghai, China

  https://orcid.org/0000-0003-2941-4808

  ⨯
•  [ ... ],
• Qiang Ding

  Roles Conceptualization, Formal analysis, Funding acquisition, Methodology, Project administration, Supervision, Validation, Writing – original draft, Writing – review & editing

  * E-mail: rong_zhang@fudan.edu.cn(RZ); qding@tsinghua.edu.cn(QD)

  Affiliations Center for Infectious Disease Research, School of Medicine, Tsinghua University, Beijing, China, Beijing Advanced Innovation Center for Structural Biology, Tsinghua University, Beijing China

  https://orcid.org/0000-0002-6226-869X

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