Viral RNA-binding ability conferred by SUMOylation at PB1 K612 of influenza A virus is essential for viral pathogenesis and transmission

Junping Li; Libin Liang; Li Jiang; Qian Wang; Xia Wen; Yuhui Zhao; Pengfei Cui; Yaping Zhang; Guangwen Wang; Qibing Li; Guohua Deng; Jianzhong Shi; Guobin Tian; Xianying Zeng; Yongping Jiang; Liling Liu; Hualan Chen; Chengjun Li

doi:10.1371/journal.ppat.1009336

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Peer-reviewed

Research Article

Viral RNA-binding ability conferred by SUMOylation at PB1 K612 of influenza A virus is essential for viral pathogenesis and transmission

Junping Li ,

Contributed equally to this work with: Junping Li, Libin Liang, Li Jiang

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Validation, Writing – original draft

Affiliation State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, The People’s Republic of China
⨯
Libin Liang ,

Contributed equally to this work with: Junping Li, Libin Liang, Li Jiang

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Validation, Writing – original draft

Affiliation State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, The People’s Republic of China
⨯
Li Jiang ,

Contributed equally to this work with: Junping Li, Libin Liang, Li Jiang

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Project administration, Supervision, Writing – original draft

Affiliation State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, The People’s Republic of China
⨯
Qian Wang,

Roles Investigation

Affiliation State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, The People’s Republic of China
⨯
Xia Wen,

Roles Investigation

Affiliation State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, The People’s Republic of China
⨯
Yuhui Zhao,

Roles Investigation

Affiliation State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, The People’s Republic of China
⨯
Pengfei Cui,

Roles Investigation

Affiliation State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, The People’s Republic of China
⨯
Yaping Zhang,

Roles Investigation

Affiliation State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, The People’s Republic of China
⨯
Guangwen Wang,

Roles Investigation

Affiliation State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, The People’s Republic of China
⨯
Qibing Li,

Roles Investigation

Affiliation State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, The People’s Republic of China
⨯
Guohua Deng,

Roles Resources

Affiliation State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, The People’s Republic of China
⨯
Jianzhong Shi,

Roles Resources

Affiliation State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, The People’s Republic of China
⨯
Guobin Tian,

Roles Resources

Affiliation State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, The People’s Republic of China
⨯
Xianying Zeng,

Roles Investigation

Affiliation State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, The People’s Republic of China
⨯
Yongping Jiang,

Roles Resources

Affiliation State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, The People’s Republic of China
⨯
Liling Liu,

Roles Investigation

Affiliation State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, The People’s Republic of China
⨯
Hualan Chen ,

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Project administration, Supervision, Writing – original draft, Writing – review & editing

* E-mail: chenhualan@caas.cn (HC); lichengjun@caas.cn (CL)

Affiliation State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, The People’s Republic of China
⨯
[ ... ],
Chengjun Li

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Project administration, Supervision, Writing – original draft, Writing – review & editing

* E-mail: chenhualan@caas.cn (HC); lichengjun@caas.cn (CL)

Affiliation State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, The People’s Republic of China

https://orcid.org/0000-0001-8460-8619

⨯
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Viral RNA-binding ability conferred by SUMOylation at PB1 K612 of influenza A virus is essential for viral pathogenesis and transmission

Junping Li,
Libin Liang,
Li Jiang,
Qian Wang,
Xia Wen,
Yuhui Zhao,
Pengfei Cui,
Yaping Zhang,
Guangwen Wang,
Qibing Li

Published: February 11, 2021
https://doi.org/10.1371/journal.ppat.1009336

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