The PB1 protein of influenza A virus inhibits the innate immune response by targeting MAVS for NBR1-mediated selective autophagic degradation

Yan Zeng; Shuai Xu; Yanli Wei; Xuegang Zhang; Qian Wang; Yane Jia; Wanbing Wang; Lu Han; Zhaoshan Chen; Zhengxiang Wang; Bo Zhang; Hualan Chen; Cao-Qi Lei; Qiyun Zhu

doi:10.1371/journal.ppat.1009300

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Open Access

Peer-reviewed

Research Article

The PB1 protein of influenza A virus inhibits the innate immune response by targeting MAVS for NBR1-mediated selective autophagic degradation

Yan Zeng ,

Contributed equally to this work with: Yan Zeng, Shuai Xu

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Writing – original draft, Writing – review & editing

Affiliation State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China
⨯
Shuai Xu ,

Contributed equally to this work with: Yan Zeng, Shuai Xu

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Software, Visualization, Writing – review & editing

Affiliation State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China
⨯
Yanli Wei,

Roles Investigation

Affiliation State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China
⨯
Xuegang Zhang,

Roles Investigation

Affiliation State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China
⨯
Qian Wang,

Roles Investigation

Affiliation State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China
⨯
Yane Jia,

Roles Investigation

Affiliation State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China
⨯
Wanbing Wang,

Roles Investigation

Affiliation State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China
⨯
Lu Han,

Roles Investigation

Affiliation State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China
⨯
Zhaoshan Chen,

Roles Investigation

Affiliation State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China
⨯
Zhengxiang Wang,

Roles Investigation

Affiliation State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China
⨯
Bo Zhang,

Roles Investigation

Affiliation State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China
⨯
Hualan Chen,

Roles Funding acquisition, Resources, Writing – review & editing

Affiliation State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China
⨯
Cao-Qi Lei ,

Roles Conceptualization, Formal analysis, Funding acquisition, Methodology, Resources, Supervision, Validation, Visualization, Writing – review & editing

* E-mail: caoqilei@whu.edu.cn (C-QL); zhuqiyun@caas.cn (QZ)

Affiliation Hubei Key Laboratory of Cell Homeostasis, Frontier Science Center for Immunology and Metabolism, State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, China
⨯
Qiyun Zhu

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Methodology, Project administration, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: caoqilei@whu.edu.cn (C-QL); zhuqiyun@caas.cn (QZ)

Affiliation State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China

https://orcid.org/0000-0003-3748-948X

⨯

The PB1 protein of influenza A virus inhibits the innate immune response by targeting MAVS for NBR1-mediated selective autophagic degradation

Yan Zeng,
Shuai Xu,
Yanli Wei,
Xuegang Zhang,
Qian Wang,
Yane Jia,
Wanbing Wang,
Lu Han,
Zhaoshan Chen,
Zhengxiang Wang

Published: February 12, 2021
https://doi.org/10.1371/journal.ppat.1009300

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Influenza viruses
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