The C3/465 glycan hole cluster in BG505 HIV-1 envelope is the major neutralizing target involved in preventing mucosal SHIV infection

• Tysheena P. Charles,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Emory Vaccine Center, Emory University, Atlanta, Georgia, United States of America, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, United States of America

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• Samantha L. Burton,

  Roles Investigation, Methodology, Validation, Writing – review & editing

  Affiliations Emory Vaccine Center, Emory University, Atlanta, Georgia, United States of America, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, United States of America

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• Prabhu S. Arunachalam,

  Roles Resources, Writing – review & editing

  Affiliation Departments of Pathology, and Microbiology and Immunology, Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, California, United States of America

  https://orcid.org/0000-0003-0090-5689

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• Christopher A. Cottrell,

  Roles Investigation, Visualization, Writing – review & editing

  Affiliation Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America

  https://orcid.org/0000-0002-3364-3083

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• Leigh M. Sewall,

  Roles Investigation, Writing – review & editing

  Affiliation Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America

  https://orcid.org/0000-0002-2020-2991

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• Venkata S. Bollimpelli,

  Roles Writing – review & editing

  Affiliations Emory Vaccine Center, Emory University, Atlanta, Georgia, United States of America, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, United States of America

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• Sailaja Gangadhara,

  Roles Investigation, Writing – review & editing

  Affiliations Emory Vaccine Center, Emory University, Atlanta, Georgia, United States of America, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, United States of America

  https://orcid.org/0000-0001-8603-628X

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• Antu K. Dey,

  Roles Resources, Writing – review & editing

  Affiliation International AIDS Vaccine Initiative, New York, New York, United States of America

  https://orcid.org/0000-0001-7438-9379

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• Andrew B. Ward,

  Roles Supervision, Visualization, Writing – review & editing

  Affiliation Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America

  https://orcid.org/0000-0001-7153-3769

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• George M. Shaw,

  Roles Resources, Writing – review & editing

  Affiliation Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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• Eric Hunter,

  Roles Conceptualization, Funding acquisition, Project administration, Resources, Writing – review & editing

  Affiliations Emory Vaccine Center, Emory University, Atlanta, Georgia, United States of America, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, United States of America, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, United States of America

  https://orcid.org/0000-0002-4273-8631

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• Rama R. Amara,

  Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Writing – review & editing

  Affiliations Emory Vaccine Center, Emory University, Atlanta, Georgia, United States of America, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, United States of America, Department of Microbiology and Immunology, Emory University, Atlanta, Georgia, United States of America

  https://orcid.org/0000-0002-6309-6797

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• Bali Pulendran,

  Roles Conceptualization, Resources, Writing – review & editing

  Affiliation Departments of Pathology, and Microbiology and Immunology, Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, California, United States of America

  https://orcid.org/0000-0001-6517-4333

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• Marit J. van Gils ,

  Roles Conceptualization, Methodology, Resources, Writing – original draft, Writing – review & editing

  * E-mail: m.j.vangils@amsterdamumc.nl (MJVG); cderdey@emory.edu (CAD)

  Affiliation Department of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands

  https://orcid.org/0000-0003-3422-8161

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• Cynthia A. Derdeyn

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: m.j.vangils@amsterdamumc.nl (MJVG); cderdey@emory.edu (CAD)

  Affiliations Emory Vaccine Center, Emory University, Atlanta, Georgia, United States of America, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, United States of America, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, United States of America

  https://orcid.org/0000-0002-1220-513X

  ⨯