Interferon signaling suppresses the unfolded protein response and induces cell death in hepatocytes accumulating hepatitis B surface antigen

• Ian Baudi ,

  Contributed equally to this work with: Ian Baudi, Masanori Isogawa

  Roles Data curation, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Department of Virology and Liver Unit, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan

  https://orcid.org/0000-0001-8645-1571

  ⨯
• Masanori Isogawa ,

  Contributed equally to this work with: Ian Baudi, Masanori Isogawa

  Roles Conceptualization, Data curation, Funding acquisition, Investigation, Methodology, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: nisogawa@niid.go.jp (MI); ytanaka@kumamoto-u.ac.jp (YT)

  Affiliations Department of Virology and Liver Unit, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan, Research Center for Drug and Vaccine Development, National Institute of Infectious Diseases, Tokyo, Japan

  https://orcid.org/0000-0001-8730-4303

  ⨯
• Federica Moalli,

  Roles Data curation, Investigation, Methodology, Writing – review & editing

  Affiliation Division of Immunology, Transplantation, and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy

  ⨯
• Masaya Onishi,

  Roles Data curation, Formal analysis, Writing – review & editing

  Affiliations Department of Virology and Liver Unit, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan, Department of Gastroenterology/Internal Medicine, Gifu University Graduate School of Medicine, Gifu, Japan

  ⨯
• Keigo Kawashima,

  Roles Data curation, Investigation, Writing – review & editing

  Affiliations Department of Virology and Liver Unit, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan, Department of Gastroenterology and Hepatology, Yokohama City University School of Medicine, Yokohama, Japan

  https://orcid.org/0000-0003-0985-1111

  ⨯
• Yuji Ishida,

  Roles Data curation

  Affiliations Research Center for Hepatology and Gastroenterology, Hiroshima University, Hiroshima, Japan, PhoenixBio Co., Ltd., Higashi-Hiroshima, Japan

  ⨯
• Chise Tateno,

  Roles Data curation

  Affiliations Research Center for Hepatology and Gastroenterology, Hiroshima University, Hiroshima, Japan, PhoenixBio Co., Ltd., Higashi-Hiroshima, Japan

  ⨯
• Yusuke Sato,

  Roles Resources, Writing – review & editing

  Affiliation Laboratory for Molecular Design of Pharmaceutics, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan

  https://orcid.org/0000-0003-0913-7815

  ⨯
• Hideyoshi Harashima,

  Roles Resources, Writing – review & editing

  Affiliation Laboratory for Molecular Design of Pharmaceutics, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan

  ⨯
• Hiroyasu Ito,

  Roles Resources, Writing – review & editing

  Affiliation Department of Joint Research Laboratory of Clinical Medicine, Fujita Health University School of Medicine, Toyoake, Japan

  https://orcid.org/0000-0002-4836-4001

  ⨯
• Tetsuya Ishikawa,

  Roles Methodology, Writing – review & editing

  Affiliation Department of Integrated Health Sciences, Nagoya University Graduate School of Medicine, Nagoya, Japan

  https://orcid.org/0000-0002-8506-4948

  ⨯
• Takaji Wakita,

  Roles Funding acquisition, Writing – review & editing

  Affiliation National Institute of Infectious Diseases, Tokyo, Japan

  ⨯
• Matteo Iannacone,

  Roles Funding acquisition, Methodology, Writing – review & editing

  Affiliation Division of Immunology, Transplantation, and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy

  https://orcid.org/0000-0002-9370-2671

  ⨯
• Yasuhito Tanaka

  Roles Funding acquisition, Supervision, Writing – review & editing

  * E-mail: nisogawa@niid.go.jp (MI); ytanaka@kumamoto-u.ac.jp (YT)

  Affiliations Department of Virology and Liver Unit, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan, Department of Gastroenterology and Hepatology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan

  https://orcid.org/0000-0002-2473-6966

  ⨯