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Functional analyses of epidemic Clostridioides difficile toxin B variants reveal their divergence in utilizing receptors and inducing pathology
- Zhenrui Pan ,
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Yuanyuan Zhang ,
Contributed equally to this work with: Zhenrui Pan, Yuanyuan Zhang, Jianhua Luo
Roles Data curation, Formal analysis, Investigation, Project administration, Validation, Writing – review & editing
Affiliations Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, China, Center for Infectious Disease Research, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China, Institute of Basic Medical Sciences, Westlake Institute for Advanced Study, Hangzhou, China
⨯ -
Jianhua Luo ,
Contributed equally to this work with: Zhenrui Pan, Yuanyuan Zhang, Jianhua Luo
Roles Data curation, Formal analysis, Investigation, Methodology, Resources, Validation, Writing – review & editing
Affiliations Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, China, Center for Infectious Disease Research, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China, Institute of Basic Medical Sciences, Westlake Institute for Advanced Study, Hangzhou, China
⨯ - Danyang Li,
- Yao Zhou,
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Liuqing He,
Roles Resources
Affiliations Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, China, Center for Infectious Disease Research, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China, Institute of Basic Medical Sciences, Westlake Institute for Advanced Study, Hangzhou, China
⨯ - Qi Yang,
-
Min Dong ,
Roles Conceptualization, Data curation, Methodology, Supervision, Visualization, Writing – review & editing
* E-mail: min.dong@childrens.harvard.edu (MD); taoliang@westlake.edu.cn (LT)
Affiliations Department of Urology, Boston Children’s Hospital, Boston, Massechusetts, United States of America, Department of Surgery and Department of Microbiology, Harvard Medical School, Boston, Massechusetts, United States of America
⨯ -
Liang Tao
Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing
* E-mail: min.dong@childrens.harvard.edu (MD); taoliang@westlake.edu.cn (LT)
Affiliations Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, China, Center for Infectious Disease Research, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China, Institute of Basic Medical Sciences, Westlake Institute for Advanced Study, Hangzhou, China
⨯
https://orcid.org/0000-0002-8062-2787
Functional analyses of epidemic Clostridioides difficile toxin B variants reveal their divergence in utilizing receptors and inducing pathology
- Zhenrui Pan,
- Yuanyuan Zhang,
- Jianhua Luo,
- Danyang Li,
- Yao Zhou,
- Liuqing He,
- Qi Yang,
- Min Dong,
- Liang Tao
- Published: January 28, 2021
- https://doi.org/10.1371/journal.ppat.1009197