Emergence of artemisinin-resistant Plasmodium falciparum with kelch13 C580Y mutations on the island of New Guinea

Olivo Miotto; Makoto Sekihara; Shin-Ichiro Tachibana; Masato Yamauchi; Richard D. Pearson; Roberto Amato; Sonia Gonçalves; Somya Mehra; Rintis Noviyanti; Jutta Marfurt; Sarah Auburn; Ric N. Price; Ivo Mueller; Mie Ikeda; Toshiyuki Mori; Makoto Hirai; Livingstone Tavul; Manuel W. Hetzel; Moses Laman; Alyssa E. Barry; Pascal Ringwald; Jun Ohashi; Francis Hombhanje; Dominic P. Kwiatkowski; Toshihiro Mita

doi:10.1371/journal.ppat.1009133

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Open Access

Peer-reviewed

Research Article

Emergence of artemisinin-resistant Plasmodium falciparum with kelch13 C580Y mutations on the island of New Guinea

Olivo Miotto ,

Contributed equally to this work with: Olivo Miotto, Makoto Sekihara

Roles Conceptualization, Data curation, Formal analysis, Investigation, Project administration, Software, Visualization, Writing – original draft, Writing – review & editing

* E-mail: olivo@tropmedres.ac (OM); tmita@juntendo.ac.jp (TM)

Affiliations MRC Centre for Genomics and Global Health, Big Data Institute, University of Oxford, Oxford, United Kingdom, Mahidol-Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, Thailand, Wellcome Sanger Institute, Hinxton, United Kingdom, Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom

https://orcid.org/0000-0001-8060-6771

⨯
Makoto Sekihara ,

Contributed equally to this work with: Olivo Miotto, Makoto Sekihara

Roles Investigation, Resources, Validation, Writing – original draft, Writing – review & editing

Affiliation Department of Tropical Medicine and Parasitology, Juntendo University Faculty of Medicine, Tokyo, Japan
⨯
Shin-Ichiro Tachibana,

Roles Investigation, Resources, Visualization

Affiliation Department of Tropical Medicine and Parasitology, Juntendo University Faculty of Medicine, Tokyo, Japan

https://orcid.org/0000-0001-5204-0336

⨯
Masato Yamauchi,

Roles Investigation, Resources

Affiliation Department of Tropical Medicine and Parasitology, Juntendo University Faculty of Medicine, Tokyo, Japan
⨯
Richard D. Pearson,

Roles Data curation, Investigation, Resources, Software

Affiliations MRC Centre for Genomics and Global Health, Big Data Institute, University of Oxford, Oxford, United Kingdom, Wellcome Sanger Institute, Hinxton, United Kingdom

https://orcid.org/0000-0002-7386-3566

⨯
Roberto Amato,

Roles Data curation, Investigation, Resources

Affiliation Wellcome Sanger Institute, Hinxton, United Kingdom

https://orcid.org/0000-0001-8633-9221

⨯
Sonia Gonçalves,

Roles Investigation, Resources

Affiliation Wellcome Sanger Institute, Hinxton, United Kingdom

https://orcid.org/0000-0003-0321-3303

⨯
Somya Mehra,

Roles Formal analysis, Investigation, Validation, Visualization

Affiliation Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia

https://orcid.org/0000-0002-0507-3204

⨯
Rintis Noviyanti,

Roles Investigation, Resources, Supervision

Affiliation Eijkman Institute for Molecular Biology, Jakarta, Indonesia

https://orcid.org/0000-0003-1383-3274

⨯
Jutta Marfurt,

Roles Investigation, Resources

Affiliation Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Australia
⨯
Sarah Auburn,

Roles Investigation, Resources

Affiliations Mahidol-Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, Thailand, Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom, Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Australia

https://orcid.org/0000-0002-4638-536X

⨯
Ric N. Price,

Roles Investigation, Resources

Affiliations Mahidol-Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, Thailand, Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom, Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Australia

https://orcid.org/0000-0003-2000-2874

⨯
Ivo Mueller,

Roles Investigation, Resources

Affiliation Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
⨯
Mie Ikeda,

Roles Investigation

Affiliation Department of Tropical Medicine and Parasitology, Juntendo University Faculty of Medicine, Tokyo, Japan
⨯
Toshiyuki Mori,

Roles Investigation

Affiliation Department of Tropical Medicine and Parasitology, Juntendo University Faculty of Medicine, Tokyo, Japan

https://orcid.org/0000-0001-8751-4562

⨯
Makoto Hirai,

Roles Investigation

Affiliation Department of Tropical Medicine and Parasitology, Juntendo University Faculty of Medicine, Tokyo, Japan
⨯
Livingstone Tavul,

Roles Resources, Supervision

Affiliation Papua New Guinea Institute of Medical Research, Madang, Papua New Guinea

https://orcid.org/0000-0002-7962-4320

⨯
Manuel W. Hetzel,

Roles Investigation, Resources

Affiliations Swiss Tropical and Public Health Institute, Basel, Switzerland, University of Basel, Basel, Switzerland

https://orcid.org/0000-0002-5285-3254

⨯
Moses Laman,

Roles Resources, Supervision

Affiliation Papua New Guinea Institute of Medical Research, Madang, Papua New Guinea

https://orcid.org/0000-0003-0964-805X

⨯
Alyssa E. Barry,

Roles Formal analysis, Investigation, Methodology, Resources, Supervision, Writing – review & editing

Affiliations Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia, University of Melbourne, Melbourne, Australia, Institute for Mental and Physical Health and Clinical Translation (IMPACT), Deakin University, Geelong, Australia, Burnet Institute, Melbourne, Australia

https://orcid.org/0000-0002-1189-2310

⨯
Pascal Ringwald,

Roles Investigation

Affiliation World Health Organization, Geneva, Switzerland
⨯
Jun Ohashi,

Roles Formal analysis, Investigation, Methodology, Resources, Supervision, Writing – review & editing

Affiliation Department of Biological Sciences, Graduate School of Science, University of Tokyo, Tokyo, Japan
⨯
Francis Hombhanje,

Roles Supervision

Affiliation Centre for Health Research & Diagnostics, Divine Word University, Madang, Papua New Guinea
⨯
Dominic P. Kwiatkowski,

Roles Funding acquisition, Resources, Supervision

Affiliations MRC Centre for Genomics and Global Health, Big Data Institute, University of Oxford, Oxford, United Kingdom, Wellcome Sanger Institute, Hinxton, United Kingdom

https://orcid.org/0000-0002-5023-0176

⨯
[ ... ],
Toshihiro Mita

Roles Conceptualization, Data curation, Funding acquisition, Investigation, Project administration, Resources, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: olivo@tropmedres.ac (OM); tmita@juntendo.ac.jp (TM)

Affiliation Department of Tropical Medicine and Parasitology, Juntendo University Faculty of Medicine, Tokyo, Japan

https://orcid.org/0000-0001-8180-2344

⨯
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Emergence of artemisinin-resistant Plasmodium falciparum with kelch13 C580Y mutations on the island of New Guinea

Olivo Miotto,
Makoto Sekihara,
Shin-Ichiro Tachibana,
Masato Yamauchi,
Richard D. Pearson,
Roberto Amato,
Sonia Gonçalves,
Somya Mehra,
Rintis Noviyanti,
Jutta Marfurt

Published: December 15, 2020
https://doi.org/10.1371/journal.ppat.1009133

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