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Open Access
Peer-reviewed
Research Article
SARS-CoV-2 spike protein promotes IL-6 trans-signaling by activation of angiotensin II receptor signaling in epithelial cells
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Tapas Patra ,
Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing
* E-mail: tapas.patra@health.slu.edu (TP); rayr@slu.edu (RR)
Affiliation Department of Internal Medicine, Saint Louis University, Missouri, United States of America
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Keith Meyer,
Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – review & editing
Affiliation Department of Internal Medicine, Saint Louis University, Missouri, United States of America
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Lizzie Geerling,
Roles Data curation, Methodology, Visualization, Writing – review & editing
Affiliation Department of Molecular Microbiology & Immunology, Saint Louis University, Missouri, United States of America
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T. Scott Isbell,
Roles Methodology, Resources, Visualization, Writing – review & editing
Affiliation Department of Pathology, Saint Louis University, Missouri, United States of America
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Daniel F. Hoft,
Roles Methodology, Resources, Visualization, Writing – review & editing
Affiliations Department of Internal Medicine, Saint Louis University, Missouri, United States of America, Department of Molecular Microbiology & Immunology, Saint Louis University, Missouri, United States of America
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James Brien,
Roles Methodology, Visualization, Writing – review & editing
Affiliation Department of Molecular Microbiology & Immunology, Saint Louis University, Missouri, United States of America
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Amelia K. Pinto,
Roles Methodology, Visualization, Writing – review & editing
Affiliation Department of Molecular Microbiology & Immunology, Saint Louis University, Missouri, United States of America
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Ratna B. Ray,
Roles Conceptualization, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – review & editing
Affiliation Department of Pathology, Saint Louis University, Missouri, United States of America
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Ranjit Ray
Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing
* E-mail: tapas.patra@health.slu.edu (TP); rayr@slu.edu (RR)
Affiliations Department of Internal Medicine, Saint Louis University, Missouri, United States of America, Department of Molecular Microbiology & Immunology, Saint Louis University, Missouri, United States of America
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SARS-CoV-2 spike protein promotes IL-6 trans-signaling by activation of angiotensin II receptor signaling in epithelial cells
- Tapas Patra,
- Keith Meyer,
- Lizzie Geerling,
- T. Scott Isbell,
- Daniel F. Hoft,
- James Brien,
- Amelia K. Pinto,
- Ratna B. Ray,
- Ranjit Ray
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- Published: December 7, 2020
- https://doi.org/10.1371/journal.ppat.1009128