Host RAB11FIP5 protein inhibits the release of Kaposi’s sarcoma-associated herpesvirus particles by promoting lysosomal degradation of ORF45

Xiaoqin Wei; Jiazhen Dong; Chin-Chen Cheng; Mingjun Ji; Lei Yu; Shengqiu Luo; Shuwen Wu; Lei Bai; Ke Lan

doi:10.1371/journal.ppat.1009099

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Open Access

Peer-reviewed

Research Article

Host RAB11FIP5 protein inhibits the release of Kaposi’s sarcoma-associated herpesvirus particles by promoting lysosomal degradation of ORF45

Xiaoqin Wei ,

Contributed equally to this work with: Xiaoqin Wei, Jiazhen Dong

Roles Conceptualization, Data curation, Formal analysis, Methodology, Writing – original draft, Writing – review & editing

Affiliation State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, China
⨯
Jiazhen Dong ,

Contributed equally to this work with: Xiaoqin Wei, Jiazhen Dong

Roles Resources, Validation, Writing – review & editing

Affiliation State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, China
⨯
Chin-Chen Cheng,

Roles Formal analysis, Investigation, Methodology

Affiliation State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, China

https://orcid.org/0000-0003-2715-9903

⨯
Mingjun Ji,

Roles Investigation, Methodology

Affiliation State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, China
⨯
Lei Yu,

Roles Methodology

Affiliation State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, China
⨯
Shengqiu Luo,

Roles Investigation, Methodology

Affiliation State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, China
⨯
Shuwen Wu,

Roles Resources

Affiliation State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, China
⨯
Lei Bai,

Roles Writing – review & editing

Affiliation State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, China
⨯
Ke Lan

Roles Conceptualization, Funding acquisition, Project administration, Writing – review & editing

* E-mail: klan@whu.edu.cn

Affiliation State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, China

https://orcid.org/0000-0002-0384-8598

⨯

Host RAB11FIP5 protein inhibits the release of Kaposi’s sarcoma-associated herpesvirus particles by promoting lysosomal degradation of ORF45

Xiaoqin Wei,
Jiazhen Dong,
Chin-Chen Cheng,
Mingjun Ji,
Lei Yu,
Shengqiu Luo,
Shuwen Wu,
Lei Bai,
Ke Lan

Published: December 14, 2020
https://doi.org/10.1371/journal.ppat.1009099

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Virions
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Lysosomes
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Immunoprecipitation
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Transfection
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Cloning
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Kaposi's sarcoma-associated herpesvirus
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Membrane proteins
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Plasmid construction
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