A natural mutation between SARS-CoV-2 and SARS-CoV determines neutralization by a cross-reactive antibody

• Nicholas C. Wu ,

  Contributed equally to this work with: Nicholas C. Wu, Meng Yuan, Sandhya Bangaru, Deli Huang

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL, United States of America, Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL, United States of America

  https://orcid.org/0000-0002-9078-6697

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• Meng Yuan ,

  Contributed equally to this work with: Nicholas C. Wu, Meng Yuan, Sandhya Bangaru, Deli Huang

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, United States of America

  https://orcid.org/0000-0001-9754-4503

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• Sandhya Bangaru ,

  Contributed equally to this work with: Nicholas C. Wu, Meng Yuan, Sandhya Bangaru, Deli Huang

  Roles Investigation, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, United States of America

  https://orcid.org/0000-0001-7994-4693

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• Deli Huang ,

  Contributed equally to this work with: Nicholas C. Wu, Meng Yuan, Sandhya Bangaru, Deli Huang

  Roles Investigation, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, United States of America

  https://orcid.org/0000-0002-6989-639X

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• Xueyong Zhu,

  Roles Investigation, Writing – review & editing

  Affiliation Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, United States of America

  https://orcid.org/0000-0002-6021-3740

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• Chang-Chun D. Lee,

  Roles Investigation, Writing – review & editing

  Affiliation Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, United States of America

  https://orcid.org/0000-0002-5470-2484

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• Hannah L. Turner,

  Roles Investigation, Writing – review & editing

  Affiliation Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, United States of America

  https://orcid.org/0000-0002-4745-8057

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• Linghang Peng,

  Roles Investigation, Writing – review & editing

  Affiliation Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, United States of America

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• Linlin Yang,

  Roles Investigation, Writing – review & editing

  Affiliation Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, United States of America

  https://orcid.org/0000-0001-5602-4157

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• Dennis R. Burton,

  Roles Funding acquisition, Resources, Writing – review & editing

  Affiliations Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, United States of America, IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, United States of America, Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA, United States of America, Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, MA, United States of America

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• David Nemazee,

  Roles Funding acquisition, Resources, Writing – review & editing

  Affiliation Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, United States of America

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• Andrew B. Ward ,

  Roles Funding acquisition, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: andrew@scripps.edu (ABW); wilson@scripps.edu (IAW)

  Affiliations Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, United States of America, IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, United States of America, Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA, United States of America

  https://orcid.org/0000-0001-7153-3769

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• Ian A. Wilson

  Roles Conceptualization, Data curation, Funding acquisition, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: andrew@scripps.edu (ABW); wilson@scripps.edu (IAW)

  Affiliations Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, United States of America, IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, United States of America, Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA, United States of America, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA, United States of America

  https://orcid.org/0000-0002-6469-2419

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