Independent genomic polymorphisms in the PknH serine threonine kinase locus during evolution of the Mycobacterium tuberculosis Complex affect virulence and host preference

• Elena Mata,

  Roles Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Grupo de Genética de Micobacterias, Universidad de Zaragoza/ISS Aragon, Zaragoza, Spain, CIBER Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain

  ⨯
• Damien Farrell,

  Roles Data curation, Formal analysis, Investigation, Software

  Affiliation School of Veterinary Medicine, Veterinary Science Centre, University College Dublin, Dublin, Ireland

  https://orcid.org/0000-0003-3020-7945

  ⨯
• Ruoyao Ma,

  Roles Data curation, Investigation, Resources, Software

  Affiliation School of Veterinary Medicine, Veterinary Science Centre, University College Dublin, Dublin, Ireland

  https://orcid.org/0000-0002-8203-9421

  ⨯
• Santiago Uranga,

  Roles Investigation

  Affiliations Grupo de Genética de Micobacterias, Universidad de Zaragoza/ISS Aragon, Zaragoza, Spain, CIBER Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain

  https://orcid.org/0000-0001-7866-2803

  ⨯
• Ana Belen Gomez,

  Roles Investigation

  Affiliations Grupo de Genética de Micobacterias, Universidad de Zaragoza/ISS Aragon, Zaragoza, Spain, CIBER Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain

  ⨯
• Marta Monzon,

  Roles Resources

  Affiliation Research Centre for Encephalopathies and Transmissible Emerging Diseases, Universidad de Zaragoza, Zaragoza, Spain

  ⨯
• Juan Badiola,

  Roles Resources

  Affiliation Research Centre for Encephalopathies and Transmissible Emerging Diseases, Universidad de Zaragoza, Zaragoza, Spain

  https://orcid.org/0000-0002-7173-7216

  ⨯
• Alberto Anel,

  Roles Funding acquisition, Supervision, Writing – original draft

  Affiliation Grupo Apoptosis, Inmunidad y Cáncer, IIS Aragón. Dpto. Bioquímica y Biología Molecular y Celular, Fac. Ciencias, Universidad de Zaragoza, Zaragoza, Spain

  ⨯
• Jesús Gonzalo-Asensio,

  Roles Writing – original draft

  Affiliations Grupo de Genética de Micobacterias, Universidad de Zaragoza/ISS Aragon, Zaragoza, Spain, CIBER Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain, Instituto de Biocomputación y Física de Sistemas Complejos (BIFI), Zaragoza, Spain

  ⨯
• Carlos Martin,

  Roles Conceptualization, Funding acquisition, Resources, Supervision, Writing – original draft, Writing – review & editing

  Affiliations Grupo de Genética de Micobacterias, Universidad de Zaragoza/ISS Aragon, Zaragoza, Spain, CIBER Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain, Servicio de Microbiología, Hospital Universitario Miguel Servet, ISS Aragon, Spain

  https://orcid.org/0000-0003-2993-5478

  ⨯
• Stephen V. Gordon ,

  Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Resources, Supervision, Visualization, Writing – original draft, Writing – review & editing

  ¶‡ These authors are joint senior authors on this work.

  Affiliation School of Veterinary Medicine, Veterinary Science Centre, University College Dublin, Dublin, Ireland

  https://orcid.org/0000-0002-4833-5542

  ⨯
• Nacho Aguilo

  Roles Conceptualization, Formal analysis, Funding acquisition, Methodology, Project administration, Resources, Supervision, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: naguilo@unizar.es

  ¶‡ These authors are joint senior authors on this work.

  Affiliations Grupo de Genética de Micobacterias, Universidad de Zaragoza/ISS Aragon, Zaragoza, Spain, CIBER Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain

  https://orcid.org/0000-0001-7897-9173

  ⨯