Foot-and-mouth disease virus VP1 target the MAVS to inhibit type-I interferon signaling and VP1 E83K mutation results in virus attenuation

• Pathum Ekanayaka ,

  Contributed equally to this work with: Pathum Ekanayaka, Seo-Yong Lee, Thilina U. B. Herath

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation College of Veterinary Medicine, Chungnam National University, Daejeon, Republic of Korea

  https://orcid.org/0000-0002-2388-3905

  ⨯
• Seo-Yong Lee ,

  Contributed equally to this work with: Pathum Ekanayaka, Seo-Yong Lee, Thilina U. B. Herath

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft

  Affiliations College of Veterinary Medicine, Chungnam National University, Daejeon, Republic of Korea, Animal and Plant Quarantine Agency, Gyeongsangbuk-do, Republic of Korea, FVC, Gyeongsangbuk-do, Republic of Korea

  https://orcid.org/0000-0001-9596-6075

  ⨯
• Thilina U. B. Herath ,

  Contributed equally to this work with: Pathum Ekanayaka, Seo-Yong Lee, Thilina U. B. Herath

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft

  Affiliation College of Veterinary Medicine, Chungnam National University, Daejeon, Republic of Korea

  https://orcid.org/0000-0002-6333-5073

  ⨯
• Jae-Hoon Kim,

  Roles Investigation

  Affiliation Laboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology, University of Science and Technology (UST), Daejeon, Republic of Korea

  https://orcid.org/0000-0002-8262-1489

  ⨯
• Tae-Hwan Kim,

  Roles Investigation, Methodology

  Affiliations College of Veterinary Medicine, Chungnam National University, Daejeon, Republic of Korea, Infectious Disease Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea

  ⨯
• Hyuncheol Lee,

  Roles Methodology

  Affiliations College of Veterinary Medicine, Chungnam National University, Daejeon, Republic of Korea, California Institute for Quantitative Biosciences, University of California, Berkeley, California, United States of America

  https://orcid.org/0000-0002-6966-1400

  ⨯
• Kiramage Chathuranga,

  Roles Methodology

  Affiliation College of Veterinary Medicine, Chungnam National University, Daejeon, Republic of Korea

  https://orcid.org/0000-0002-0279-2895

  ⨯
• W. A. Gayan Chathuranga,

  Roles Methodology

  Affiliation College of Veterinary Medicine, Chungnam National University, Daejeon, Republic of Korea

  https://orcid.org/0000-0001-8348-727X

  ⨯
• Jong-Hyeon Park ,

  Roles Conceptualization, Formal analysis, Project administration, Resources, Supervision, Validation, Writing – original draft

  * E-mail: parkjhvet@korea.kr (J-HP); jongsool@cnu.ac.kr (J-SL)

  Affiliation Animal and Plant Quarantine Agency, Gyeongsangbuk-do, Republic of Korea

  ⨯
• Jong-Soo Lee

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Project administration, Resources, Supervision, Validation, Writing – original draft, Writing – review & editing

  * E-mail: parkjhvet@korea.kr (J-HP); jongsool@cnu.ac.kr (J-SL)

  Affiliation College of Veterinary Medicine, Chungnam National University, Daejeon, Republic of Korea

  https://orcid.org/0000-0001-5119-0711

  ⨯