Astrocytes promote a protective immune response to brain Toxoplasma gondii infection via IL-33-ST2 signaling

• Katherine M. Still,

  Roles Conceptualization, Formal analysis, Investigation, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Center for Brain Immunology and Glia, Department of Neuroscience, University of Virginia, Charlottesville, Virginia, United States of America

  https://orcid.org/0000-0003-0260-2606

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• Samantha J. Batista,

  Roles Investigation, Writing – review & editing

  Affiliation Center for Brain Immunology and Glia, Department of Neuroscience, University of Virginia, Charlottesville, Virginia, United States of America

  https://orcid.org/0000-0002-8200-7550

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• Carleigh A. O’Brien,

  Roles Investigation

  Affiliation Center for Brain Immunology and Glia, Department of Neuroscience, University of Virginia, Charlottesville, Virginia, United States of America

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• Oyebola O. Oyesola,

  Roles Investigation

  Affiliations Baker Institute for Animal Health and Department of Microbiology and Immunology, Cornell University, Ithaca, New York, United States of America, Department of Immunology, University of Washington, Seattle, Washington, United States of America

  https://orcid.org/0000-0002-5347-7502

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• Simon P. Früh,

  Roles Investigation

  Affiliation Baker Institute for Animal Health and Department of Microbiology and Immunology, Cornell University, Ithaca, New York, United States of America

  https://orcid.org/0000-0002-4757-8315

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• Lauren M. Webb,

  Roles Investigation

  Affiliation Department of Immunology, University of Washington, Seattle, Washington, United States of America

  https://orcid.org/0000-0002-1903-7570

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• Igor Smirnov,

  Roles Investigation

  Affiliation Center for Brain Immunology and Glia, Department of Neuroscience, University of Virginia, Charlottesville, Virginia, United States of America

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• Michael A. Kovacs,

  Roles Investigation, Writing – review & editing

  Affiliation Center for Brain Immunology and Glia, Department of Neuroscience, University of Virginia, Charlottesville, Virginia, United States of America

  https://orcid.org/0000-0002-4298-9609

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• Maureen N. Cowan,

  Roles Investigation

  Affiliation Center for Brain Immunology and Glia, Department of Neuroscience, University of Virginia, Charlottesville, Virginia, United States of America

  https://orcid.org/0000-0001-6842-8175

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• Nikolas W. Hayes,

  Roles Conceptualization, Investigation

  Affiliation Center for Brain Immunology and Glia, Department of Neuroscience, University of Virginia, Charlottesville, Virginia, United States of America

  https://orcid.org/0000-0003-1885-1850

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• Jeremy A. Thompson,

  Roles Investigation

  Affiliation Center for Brain Immunology and Glia, Department of Neuroscience, University of Virginia, Charlottesville, Virginia, United States of America

  https://orcid.org/0000-0001-9937-1888

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• Elia D. Tait Wojno,

  Roles Funding acquisition, Investigation, Resources

  Affiliation Department of Immunology, University of Washington, Seattle, Washington, United States of America

  https://orcid.org/0000-0003-2822-296X

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• Tajie H. Harris

  Roles Conceptualization, Funding acquisition, Investigation, Project administration, Supervision, Validation, Writing – review & editing

  * E-mail: tajieharris@virginia.edu

  Affiliation Center for Brain Immunology and Glia, Department of Neuroscience, University of Virginia, Charlottesville, Virginia, United States of America

  https://orcid.org/0000-0002-1355-2109

  ⨯