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Open Access
Peer-reviewed
Research Article
KSHV G-protein coupled receptor vGPCR oncogenic signaling upregulation of Cyclooxygenase-2 expression mediates angiogenesis and tumorigenesis in Kaposi’s sarcoma
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María Victoria Medina ,
Contributed equally to this work with: María Victoria Medina, Agata D´Agostino
Roles Data curation, Formal analysis, Investigation, Methodology, Software, Visualization, Writing – original draft, Writing – review & editing
Affiliations Universidad de Buenos Aires, Facultad de Ciencias Exactas y Naturales, Departamento de Fisiología y Biología Molecular, Buenos Aires, Argentina, CONICET-Universidad de Buenos Aires, Instituto de Fisiología, Biología Molecular y Neurociencias (IFIBYNE), Buenos Aires, Argentina, UM-CFAR/ Sylvester CCC Argentina Consortium for Research and Training in Virally induced AIDS-Malignancies, University of Miami Miller School of Medicine, Miami, Florida, United States of America
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Agata D´Agostino ,
Contributed equally to this work with: María Victoria Medina, Agata D´Agostino
Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing
Affiliation Tumor Biology Program, Sylvester Comprehensive Cancer Center and Miami Center for AIDS Research, Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, Florida, United States of America
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Qi Ma,
Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization
Affiliation Tumor Biology Program, Sylvester Comprehensive Cancer Center and Miami Center for AIDS Research, Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, Florida, United States of America
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Pilar Eroles,
Roles Investigation
Affiliation Tumor Biology Program, Sylvester Comprehensive Cancer Center and Miami Center for AIDS Research, Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, Florida, United States of America
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Lucas Cavallin,
Roles Data curation, Investigation, Methodology
Affiliation Tumor Biology Program, Sylvester Comprehensive Cancer Center and Miami Center for AIDS Research, Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, Florida, United States of America
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Chiara Chiozzini,
Roles Investigation, Methodology
Affiliations Tumor Biology Program, Sylvester Comprehensive Cancer Center and Miami Center for AIDS Research, Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, Florida, United States of America, Laboratorio di Virologia, Istituto Superiore di Sanita, Rome, Italy
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Daiana Sapochnik,
Roles Resources
Affiliations Universidad de Buenos Aires, Facultad de Ciencias Exactas y Naturales, Departamento de Fisiología y Biología Molecular, Buenos Aires, Argentina, CONICET-Universidad de Buenos Aires, Instituto de Fisiología, Biología Molecular y Neurociencias (IFIBYNE), Buenos Aires, Argentina
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Cora Cymeryng,
Roles Formal analysis, Methodology, Resources
Affiliations Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Centro de Estudios Farmacológicos y Botánicos (CEFYBO), Facultad de Medicina. Buenos Aires, Argentina, Universidad de Buenos Aires, Facultad de Medicina, Departamento de Bioquímica Humana, Buenos Aires, Argentina
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Elizabeth Hyjek,
Roles Validation
Affiliations Department of Pathology, The University of Chicago, Chicago, Illinois, United States of America, Department of Pathology, Weill Medical College of Cornell University, New York, New York, United States of America
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Ethel Cesarman,
Roles Data curation, Methodology, Resources, Validation
Affiliation Department of Pathology, Weill Medical College of Cornell University, New York, New York, United States of America
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Julian Naipauer ,
Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Supervision, Visualization, Writing – original draft, Writing – review & editing
* E-mail: juliannaipauer@gmail.com (JN); emesri@med.miami.edu (EAM); omar.coso@gmail.com (OAC)
Affiliations UM-CFAR/ Sylvester CCC Argentina Consortium for Research and Training in Virally induced AIDS-Malignancies, University of Miami Miller School of Medicine, Miami, Florida, United States of America, Tumor Biology Program, Sylvester Comprehensive Cancer Center and Miami Center for AIDS Research, Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, Florida, United States of America
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Enrique A. Mesri ,
Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Resources, Supervision, Validation, Writing – original draft, Writing – review & editing
* E-mail: juliannaipauer@gmail.com (JN); emesri@med.miami.edu (EAM); omar.coso@gmail.com (OAC)
Affiliations UM-CFAR/ Sylvester CCC Argentina Consortium for Research and Training in Virally induced AIDS-Malignancies, University of Miami Miller School of Medicine, Miami, Florida, United States of America, Tumor Biology Program, Sylvester Comprehensive Cancer Center and Miami Center for AIDS Research, Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, Florida, United States of America
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Omar A. Coso
Roles Conceptualization, Formal analysis, Funding acquisition, Methodology, Project administration, Resources, Supervision, Validation, Writing – review & editing
* E-mail: juliannaipauer@gmail.com (JN); emesri@med.miami.edu (EAM); omar.coso@gmail.com (OAC)
Affiliations Universidad de Buenos Aires, Facultad de Ciencias Exactas y Naturales, Departamento de Fisiología y Biología Molecular, Buenos Aires, Argentina, CONICET-Universidad de Buenos Aires, Instituto de Fisiología, Biología Molecular y Neurociencias (IFIBYNE), Buenos Aires, Argentina, UM-CFAR/ Sylvester CCC Argentina Consortium for Research and Training in Virally induced AIDS-Malignancies, University of Miami Miller School of Medicine, Miami, Florida, United States of America
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KSHV G-protein coupled receptor vGPCR oncogenic signaling upregulation of Cyclooxygenase-2 expression mediates angiogenesis and tumorigenesis in Kaposi’s sarcoma
- María Victoria Medina,
- Agata D´Agostino,
- Qi Ma,
- Pilar Eroles,
- Lucas Cavallin,
- Chiara Chiozzini,
- Daiana Sapochnik,
- Cora Cymeryng,
- Elizabeth Hyjek,
- Ethel Cesarman
![PLOS](/resource/img/logo-plos.png)
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- Published: October 15, 2020
- https://doi.org/10.1371/journal.ppat.1009006