Elicitation of potent serum neutralizing antibody responses in rabbits by immunization with an HIV-1 clade C trimeric Env derived from an Indian elite neutralizer

• Rajesh Kumar ,

  Contributed equally to this work with: Rajesh Kumar, Suprit Deshpande

  Roles Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliation Translational Health Science & Technology Institute, NCR Biotech Science Cluster, Faridabad, India

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• Suprit Deshpande ,

  Contributed equally to this work with: Rajesh Kumar, Suprit Deshpande

  Roles Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliation Translational Health Science & Technology Institute, NCR Biotech Science Cluster, Faridabad, India

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• Leigh M. Sewall,

  Roles Formal analysis, Investigation, Visualization

  Affiliations Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America, Scripps Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, California, United States of America, IAVI Neutralizing Antibody Center and the Collaboration for AIDS Vaccine Discovery (CAVD), The Scripps Research Institute, La Jolla, California, United States of America

  https://orcid.org/0000-0002-2020-2991

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• Gabriel Ozorowski,

  Roles Data curation, Formal analysis, Investigation, Methodology, Supervision, Validation, Visualization, Writing – review & editing

  Affiliations Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America, Scripps Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, California, United States of America, IAVI Neutralizing Antibody Center and the Collaboration for AIDS Vaccine Discovery (CAVD), The Scripps Research Institute, La Jolla, California, United States of America

  https://orcid.org/0000-0002-9695-8138

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• Christopher A. Cottrell,

  Roles Formal analysis, Investigation, Visualization

  Affiliations Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America, Scripps Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, California, United States of America, IAVI Neutralizing Antibody Center and the Collaboration for AIDS Vaccine Discovery (CAVD), The Scripps Research Institute, La Jolla, California, United States of America

  https://orcid.org/0000-0002-3364-3083

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• Wen-Hsin Lee,

  Roles Formal analysis, Investigation

  Affiliations Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America, Scripps Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, California, United States of America, IAVI Neutralizing Antibody Center and the Collaboration for AIDS Vaccine Discovery (CAVD), The Scripps Research Institute, La Jolla, California, United States of America

  https://orcid.org/0000-0001-9445-6671

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• Lauren G. Holden,

  Roles Investigation

  Affiliations Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America, Scripps Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, California, United States of America, IAVI Neutralizing Antibody Center and the Collaboration for AIDS Vaccine Discovery (CAVD), The Scripps Research Institute, La Jolla, California, United States of America

  https://orcid.org/0000-0001-8014-4503

  ⨯
• Sara T. Richey,

  Roles Investigation

  Affiliations Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America, Scripps Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, California, United States of America, IAVI Neutralizing Antibody Center and the Collaboration for AIDS Vaccine Discovery (CAVD), The Scripps Research Institute, La Jolla, California, United States of America

  https://orcid.org/0000-0001-7854-1833

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• Antra Singh Chandrawacar,

  Roles Data curation, Investigation

  Affiliations CSIR-Institute of Microbial Technology (IMTECH), Chandigarh, India, Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India

  https://orcid.org/0000-0002-9236-2003

  ⨯
• Kanika Dhiman,

  Roles Formal analysis, Investigation

  Affiliation CSIR-Institute of Microbial Technology (IMTECH), Chandigarh, India

  ⨯
• Ashish,

  Roles Data curation, Formal analysis, Investigation, Software, Validation, Visualization, Writing – review & editing

  Affiliations CSIR-Institute of Microbial Technology (IMTECH), Chandigarh, India, Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India

  ⨯
• Vivek Kumar,

  Roles Investigation

  Affiliation Translational Health Science & Technology Institute, NCR Biotech Science Cluster, Faridabad, India

  ⨯
• Shubbir Ahmed,

  Roles Investigation, Methodology

  Affiliation Translational Health Science & Technology Institute, NCR Biotech Science Cluster, Faridabad, India

  https://orcid.org/0000-0003-1655-6735

  ⨯
• Nitin Hingankar,

  Roles Investigation, Validation

  Affiliation Translational Health Science & Technology Institute, NCR Biotech Science Cluster, Faridabad, India

  ⨯
• Naresh Kumar,

  Roles Investigation, Methodology

  Affiliation Translational Health Science & Technology Institute, NCR Biotech Science Cluster, Faridabad, India

  ⨯
• Kailapuri G. Murugavel,

  Roles Resources

  Affiliation Y. R. Gaitonde Centre for AIDS Research and Education, YRG CARE Laboratory, Rajiv Gandhi Salai, Adyar, Chennai, India

  ⨯
• Aylur K. Srikrishnan,

  Roles Resources

  Affiliation Y. R. Gaitonde Centre for AIDS Research and Education, YRG CARE Laboratory, Rajiv Gandhi Salai, Adyar, Chennai, India

  ⨯
• Devin Sok,

  Roles Formal analysis, Methodology, Validation, Writing – review & editing

  Affiliations Scripps Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, California, United States of America, IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America, Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, United States of America, International AIDS Vaccine Initiative (IAVI), New York, United States of America

  https://orcid.org/0000-0002-9354-1740

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• Andrew B. Ward,

  Roles Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation

  Affiliations Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America, Scripps Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, California, United States of America, IAVI Neutralizing Antibody Center and the Collaboration for AIDS Vaccine Discovery (CAVD), The Scripps Research Institute, La Jolla, California, United States of America

  https://orcid.org/0000-0001-7153-3769

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•  [ ... ],
• Jayanta Bhattacharya

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: JBhattacharya@iavi.org

  Affiliations Translational Health Science & Technology Institute, NCR Biotech Science Cluster, Faridabad, India, International AIDS Vaccine Initiative, New Delhi, India; International AIDS Vaccine Initiative, New York, New York, United States of America

  https://orcid.org/0000-0002-1531-3822

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