Virulence and pathogenesis of SARS-CoV-2 infection in rhesus macaques: A nonhuman primate model of COVID-19 progression

Huiwen Zheng; Heng Li; Lei Guo; Yan Liang; Jing Li; Xi Wang; Yunguang Hu; Lichun Wang; Yun Liao; Fengmei Yang; Yanyan Li; Shengtao Fan; Dandan Li; Pingfang Cui; Qingling Wang; Haijing Shi; Yanli Chen; Zening Yang; Jinling Yang; Dong Shen; Wei Cun; Xiaofang Zhou; Xingqi Dong; Yunchuan Wang; Yong Chen; Qing Dai; Weihua Jin; Zhanlong He; Qihan Li; Longding Liu

doi:10.1371/journal.ppat.1008949

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Open Access

Peer-reviewed

Research Article

Virulence and pathogenesis of SARS-CoV-2 infection in rhesus macaques: A nonhuman primate model of COVID-19 progression

Huiwen Zheng ,

Contributed equally to this work with: Huiwen Zheng, Heng Li, Lei Guo, Yan Liang, Jing Li

Roles Data curation, Methodology, Project administration, Visualization, Writing – original draft

Affiliation Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, Yunnan Province, People’s Republic of China
⨯
Heng Li ,

Contributed equally to this work with: Huiwen Zheng, Heng Li, Lei Guo, Yan Liang, Jing Li

Roles Methodology, Writing – original draft

Affiliation Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, Yunnan Province, People’s Republic of China
⨯
Lei Guo ,

Contributed equally to this work with: Huiwen Zheng, Heng Li, Lei Guo, Yan Liang, Jing Li

Roles Methodology, Project administration, Writing – original draft

Affiliation Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, Yunnan Province, People’s Republic of China
⨯
Yan Liang ,

Contributed equally to this work with: Huiwen Zheng, Heng Li, Lei Guo, Yan Liang, Jing Li

Roles Methodology, Writing – original draft

Affiliation Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, Yunnan Province, People’s Republic of China
⨯
Jing Li ,

Contributed equally to this work with: Huiwen Zheng, Heng Li, Lei Guo, Yan Liang, Jing Li

Roles Data curation, Methodology, Project administration, Writing – original draft

Affiliation Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, Yunnan Province, People’s Republic of China
⨯
Xi Wang,

Roles Methodology, Writing – original draft

Affiliation Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, Yunnan Province, People’s Republic of China
⨯
Yunguang Hu,

Roles Methodology, Writing – original draft

Affiliation Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, Yunnan Province, People’s Republic of China
⨯
Lichun Wang,

Roles Methodology, Writing – original draft

Affiliation Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, Yunnan Province, People’s Republic of China
⨯
Yun Liao,

Roles Methodology, Writing – original draft

Affiliation Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, Yunnan Province, People’s Republic of China
⨯
Fengmei Yang,

Roles Validation, Writing – original draft

Affiliation Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, Yunnan Province, People’s Republic of China
⨯
Yanyan Li,

Roles Validation, Writing – original draft

Affiliation Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, Yunnan Province, People’s Republic of China
⨯
Shengtao Fan,

Roles Validation, Writing – original draft

Affiliation Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, Yunnan Province, People’s Republic of China
⨯
Dandan Li,

Roles Validation, Writing – original draft

Affiliation Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, Yunnan Province, People’s Republic of China

https://orcid.org/0000-0002-3527-3522

⨯
Pingfang Cui,

Roles Validation, Writing – original draft

Affiliation Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, Yunnan Province, People’s Republic of China
⨯
Qingling Wang,

Roles Visualization, Writing – original draft

Affiliation Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, Yunnan Province, People’s Republic of China
⨯
Haijing Shi,

Roles Project administration, Writing – original draft

Affiliation Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, Yunnan Province, People’s Republic of China
⨯
Yanli Chen,

Roles Visualization, Writing – original draft

Affiliation Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, Yunnan Province, People’s Republic of China
⨯
Zening Yang,

Roles Visualization, Writing – original draft

Affiliation Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, Yunnan Province, People’s Republic of China
⨯
Jinling Yang,

Roles Visualization, Writing – original draft

Affiliation Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, Yunnan Province, People’s Republic of China
⨯
Dong Shen,

Roles Visualization, Writing – original draft

Affiliation Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, Yunnan Province, People’s Republic of China
⨯
Wei Cun,

Roles Methodology, Writing – original draft

Affiliation Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, Yunnan Province, People’s Republic of China
⨯
Xiaofang Zhou,

Roles Resources, Writing – original draft

Affiliation Yunnan Provincial Center for Disease Control and Prevention, Kunming, Yunnan Province, People’s Republic of China
⨯
Xingqi Dong,

Roles Resources, Writing – original draft

Affiliation Yunnan Provincial Infectious Disease Hospital, Kunming, Yunnan Province, People’s Republic of China
⨯
Yunchuan Wang,

Roles Resources, Writing – original draft

Affiliation Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, Yunnan Province, People’s Republic of China
⨯
Yong Chen,

Roles Resources, Writing – original draft

Affiliation Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, Yunnan Province, People’s Republic of China
⨯
Qing Dai,

Roles Resources, Supervision, Writing – original draft

Affiliation Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, Yunnan Province, People’s Republic of China
⨯
Weihua Jin,

Roles Validation, Writing – original draft

Affiliation Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, Yunnan Province, People’s Republic of China
⨯
Zhanlong He ,

Roles Conceptualization, Formal analysis, Investigation, Resources, Supervision, Writing – original draft

* E-mail: hzl@imbcams.com.cn(ZH); liqihan@imbcams.com.cn(QL); longdingl@gmail.com (LL)

¶‡ ZH, QL and LL also contributed equally to this work. LL is the lead contact.

Affiliation Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, Yunnan Province, People’s Republic of China
⨯
Qihan Li ,

Roles Conceptualization, Formal analysis, Investigation, Supervision, Writing – original draft, Writing – review & editing

* E-mail: hzl@imbcams.com.cn(ZH); liqihan@imbcams.com.cn(QL); longdingl@gmail.com (LL)

¶‡ ZH, QL and LL also contributed equally to this work. LL is the lead contact.

Affiliation Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, Yunnan Province, People’s Republic of China
⨯
[ ... ],
Longding Liu

Roles Conceptualization, Data curation, Formal analysis, Investigation, Supervision, Writing – original draft, Writing – review & editing

* E-mail: hzl@imbcams.com.cn(ZH); liqihan@imbcams.com.cn(QL); longdingl@gmail.com (LL)

¶‡ ZH, QL and LL also contributed equally to this work. LL is the lead contact.

Affiliation Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, Yunnan Province, People’s Republic of China

https://orcid.org/0000-0001-8335-5613

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Virulence and pathogenesis of SARS-CoV-2 infection in rhesus macaques: A nonhuman primate model of COVID-19 progression

Huiwen Zheng,
Heng Li,
Lei Guo,
Yan Liang,
Jing Li,
Xi Wang,
Yunguang Hu,
Lichun Wang,
Yun Liao,
Fengmei Yang

Published: November 12, 2020
https://doi.org/10.1371/journal.ppat.1008949

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