Veterinary trypanocidal benzoxaboroles are peptidase-activated prodrugs

• Federica Giordani ,

  Contributed equally to this work with: Federica Giordani, Daniel Paape

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Wellcome Centre for Integrative Parasitology, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom

  https://orcid.org/0000-0001-9964-281X

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• Daniel Paape ,

  Contributed equally to this work with: Federica Giordani, Daniel Paape

  Roles Formal analysis, Investigation, Project administration, Validation, Writing – original draft

  Affiliation Wellcome Centre for Integrative Parasitology, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom

  https://orcid.org/0000-0003-4355-8058

  ⨯
• Isabel M. Vincent,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliation Wellcome Centre for Integrative Parasitology, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom

  https://orcid.org/0000-0003-2663-4389

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• Andrew W. Pountain,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Software, Visualization, Writing – review & editing

  Affiliation Wellcome Centre for Integrative Parasitology, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom

  https://orcid.org/0000-0001-9651-5145

  ⨯
• Fernando Fernández-Cortés,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Writing – review & editing

  Affiliation Wellcome Centre for Integrative Parasitology, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom

  https://orcid.org/0000-0001-9362-2164

  ⨯
• Eva Rico,

  Roles Investigation, Methodology, Validation

  Affiliation Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, United Kingdom

  ⨯
• Ning Zhang,

  Roles Conceptualization, Investigation, Methodology

  Affiliation Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, United Kingdom

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• Liam J. Morrison,

  Roles Conceptualization, Funding acquisition, Validation, Writing – review & editing

  Affiliation Roslin Institute, Royal (Dick) School of Veterinary Studies, University of Edinburgh, Midlothian, United Kingdom

  https://orcid.org/0000-0002-8304-9066

  ⨯
• Yvonne Freund,

  Roles Conceptualization, Formal analysis, Funding acquisition, Writing – review & editing

  Affiliation Anacor Pharmaceuticals, Inc., Palo Alto, California, United States of America

  ⨯
• Michael J. Witty,

  Roles Conceptualization, Funding acquisition, Writing – review & editing

  Affiliation Global Alliance for Livestock and Veterinary Medicine, Pentlands Science Park, Penicuik, Edinburgh, United Kingdom

  https://orcid.org/0000-0003-4094-7154

  ⨯
• Rosemary Peter,

  Roles Conceptualization, Funding acquisition, Project administration, Writing – review & editing

  Affiliation Global Alliance for Livestock and Veterinary Medicine, Pentlands Science Park, Penicuik, Edinburgh, United Kingdom

  ⨯
• Darren Y. Edwards,

  Roles Investigation, Methodology, Validation

  Affiliation Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, United Kingdom

  https://orcid.org/0000-0001-8245-8928

  ⨯
• Jonathan M. Wilkes,

  Roles Formal analysis, Methodology, Software

  Affiliation Wellcome Centre for Integrative Parasitology, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom

  ⨯
• Justin J. J. van der Hooft,

  Roles Data curation, Methodology, Writing – review & editing

  Affiliations Glasgow Polyomics, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom, Current address: Bioinformatics Group, Wageningen University, Wageningen, the Netherlands

  https://orcid.org/0000-0002-9340-5511

  ⨯
• Clément Regnault,

  Roles Data curation, Investigation, Methodology

  Affiliation Glasgow Polyomics, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom

  ⨯
• Kevin D. Read,

  Roles Conceptualization, Methodology, Validation

  Affiliation Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, United Kingdom

  https://orcid.org/0000-0002-8536-0130

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• David Horn,

  Roles Conceptualization, Investigation, Supervision, Writing – review & editing

  Affiliation Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, United Kingdom

  https://orcid.org/0000-0001-5173-9284

  ⨯
• Mark C. Field,

  Roles Formal analysis, Methodology, Supervision, Writing – review & editing

  Affiliations Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, United Kingdom, Institute of Parasitology, Biology Centre of the Czech Academy of Sciences, České Budějovice, Czech Republic

  https://orcid.org/0000-0002-4866-2885

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•  [ ... ],
• Michael P. Barrett

  Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Writing – review & editing

  * E-mail: michael.barrett@glasgow.ac.uk

  Affiliations Wellcome Centre for Integrative Parasitology, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom, Glasgow Polyomics, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom

  https://orcid.org/0000-0001-9447-3519

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