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Open Access
Peer-reviewed
Research Article
Recognition of a highly conserved glycoprotein B epitope by a bivalent antibody neutralizing HCMV at a post-attachment step
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Xiaohua Ye ,
Contributed equally to this work with: Xiaohua Ye, Hang Su, Daniel Wrapp
Roles Conceptualization, Data curation, Investigation, Methodology, Writing – original draft, Writing – review & editing
Affiliation Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, Texas, United States of America
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Hang Su ,
Contributed equally to this work with: Xiaohua Ye, Hang Su, Daniel Wrapp
Roles Data curation, Investigation
Affiliations Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, Texas, United States of America, Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, China
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Daniel Wrapp ,
Contributed equally to this work with: Xiaohua Ye, Hang Su, Daniel Wrapp
Roles Data curation, Investigation, Methodology, Writing – original draft
Affiliation Department of Molecular Biosciences, University of Texas at Austin, Austin, Texas, United States of America
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Daniel C. Freed,
Roles Data curation, Investigation, Methodology
Affiliation Merck Research Laboratory, Merck & Co., Inc., Kenilworth, New Jersey, United States of America
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Fengsheng Li,
Roles Data curation, Methodology
Affiliation Merck Research Laboratory, Merck & Co., Inc., Kenilworth, New Jersey, United States of America
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Zihao Yuan,
Roles Data curation, Methodology, Software
Affiliation Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, Texas, United States of America
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Aimin Tang,
Roles Data curation, Methodology
Affiliation Merck Research Laboratory, Merck & Co., Inc., Kenilworth, New Jersey, United States of America
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Leike Li,
Roles Resources
Affiliation Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, Texas, United States of America
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Zhiqiang Ku,
Roles Resources
Affiliation Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, Texas, United States of America
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Wei Xiong,
Roles Resources
Affiliation Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, Texas, United States of America
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Dabbu Jaijyan,
Roles Resources
Affiliation Department of Microbiology, Biochemistry and Molecular Genetics, Rutgers New Jersey Medical School, Newark, New Jersey, United States of America
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Hua Zhu,
Roles Resources
Affiliation Department of Microbiology, Biochemistry and Molecular Genetics, Rutgers New Jersey Medical School, Newark, New Jersey, United States of America
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Dai Wang,
Roles Resources
Affiliation Merck Research Laboratory, Merck & Co., Inc., Kenilworth, New Jersey, United States of America
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Jason S. McLellan,
Roles Data curation, Formal analysis, Methodology
Affiliation Department of Molecular Biosciences, University of Texas at Austin, Austin, Texas, United States of America
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Ningyan Zhang ,
Roles Supervision, Writing – review & editing
* E-mail: ningyan.zhang@uth.tmc.edu (NZ); Tong-Ming.Fu@uth.tmc.edu (TMF); zhiqiang.an@uth.tmc.edu (ZA)
Affiliation Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, Texas, United States of America
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Tong-Ming Fu ,
Roles Conceptualization, Data curation, Formal analysis, Supervision, Writing – review & editing
* E-mail: ningyan.zhang@uth.tmc.edu (NZ); Tong-Ming.Fu@uth.tmc.edu (TMF); zhiqiang.an@uth.tmc.edu (ZA)
Affiliations Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, Texas, United States of America, Merck Research Laboratory, Merck & Co., Inc., Kenilworth, New Jersey, United States of America
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Zhiqiang An
Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing
* E-mail: ningyan.zhang@uth.tmc.edu (NZ); Tong-Ming.Fu@uth.tmc.edu (TMF); zhiqiang.an@uth.tmc.edu (ZA)
Affiliation Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, Texas, United States of America
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Recognition of a highly conserved glycoprotein B epitope by a bivalent antibody neutralizing HCMV at a post-attachment step
- Xiaohua Ye,
- Hang Su,
- Daniel Wrapp,
- Daniel C. Freed,
- Fengsheng Li,
- Zihao Yuan,
- Aimin Tang,
- Leike Li,
- Zhiqiang Ku,
- Wei Xiong
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- Published: August 3, 2020
- https://doi.org/10.1371/journal.ppat.1008736