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Open Access
Peer-reviewed
Research Article
Site-directed M2 proton channel inhibitors enable synergistic combination therapy for rimantadine-resistant pandemic influenza
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Claire Scott,
Roles Investigation
Current address: Covance, Springfield House, West Yorkshire, United Kingdom
Affiliations Leeds Institute of Medical Research, School of Medicine, Faculty of Medicine and Health, St James’s University Hospital, University of Leeds, Leeds, West Yorkshire, United Kingdom, Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, West Yorkshire, United Kingdom
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Jayakanth Kankanala,
Roles Investigation, Methodology
Current address: Centre for Drug Design, University of Minnesota, Nils Hasselmo Hall, Minneapolis, United States of America
Affiliations Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, West Yorkshire, United Kingdom, School of Chemistry, Faculty of Mathematics and Physical Sciences, University of Leeds, Leeds, West Yorkshire, United Kingdom
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Toshana L. Foster,
Roles Investigation, Methodology
Current address: Faculty of Medicine & Health Sciences, University of Nottingham, Sutton Bonington Campus, Sutton Bonington, Leicestershire, United Kingdom
Affiliations Leeds Institute of Medical Research, School of Medicine, Faculty of Medicine and Health, St James’s University Hospital, University of Leeds, Leeds, West Yorkshire, United Kingdom, Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, West Yorkshire, United Kingdom
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Daniel H. Goldhill,
Roles Data curation, Formal analysis, Investigation
Affiliation Faculty of Medicine, Section of Virology, Imperial College, London, United Kingdom
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Peng Bao,
Roles Investigation, Methodology
Affiliation Faculty of Engineering and Physical Sciences, School of Physics and Astronomy, University of Leeds, Leeds, West Yorkshire, United Kingdom
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Katie Simmons,
Roles Formal analysis, Investigation, Methodology
Affiliations Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, West Yorkshire, United Kingdom, School of Chemistry, Faculty of Mathematics and Physical Sciences, University of Leeds, Leeds, West Yorkshire, United Kingdom
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Marieke Pingen,
Roles Investigation
Current address: Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom
Affiliation Leeds Institute of Medical Research, School of Medicine, Faculty of Medicine and Health, St James’s University Hospital, University of Leeds, Leeds, West Yorkshire, United Kingdom
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Matthew Bentham,
Roles Investigation
Affiliations Leeds Institute of Medical Research, School of Medicine, Faculty of Medicine and Health, St James’s University Hospital, University of Leeds, Leeds, West Yorkshire, United Kingdom, Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, West Yorkshire, United Kingdom
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Elizabeth Atkins,
Roles Investigation, Methodology
Current address: London School of Hygiene & Tropical Medicine, London, United Kingdom
Affiliations Leeds Institute of Medical Research, School of Medicine, Faculty of Medicine and Health, St James’s University Hospital, University of Leeds, Leeds, West Yorkshire, United Kingdom, Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, West Yorkshire, United Kingdom
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Eleni Loundras,
Roles Investigation
Affiliations Leeds Institute of Medical Research, School of Medicine, Faculty of Medicine and Health, St James’s University Hospital, University of Leeds, Leeds, West Yorkshire, United Kingdom, Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, West Yorkshire, United Kingdom
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Ruth Elderfield,
Roles Methodology, Supervision
Current address: Public Health England, Porton Down, Wiltshire,
Affiliation Faculty of Medicine, Section of Virology, Imperial College, London, United Kingdom
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Jolyon K. Claridge,
Roles Investigation
Current address: Structural and Molecular Microbiology, Structural Biology Research Centre, Vrije Universiteit Brussel, Pleinlaan, Brussels, Belgium
Affiliation Department of Biochemistry, University of Oxford, Oxford, United Kingdom
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Joseph Thompson,
Roles Investigation, Methodology
Current address: School of Medicine, King's College London, Strand, London, England, United Kingdom
Affiliations Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, West Yorkshire, United Kingdom, School of Chemistry, Faculty of Mathematics and Physical Sciences, University of Leeds, Leeds, West Yorkshire, United Kingdom
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Peter R. Stilwell,
Roles Investigation, Methodology
Current address: Environment and Sustainability Institute, University of Exeter, Penryn Campus, Penryn, Cornwall, United Kingdom
Affiliation Faculty of Medicine, Section of Virology, Imperial College, London, United Kingdom
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Ranjitha Tathineni,
Roles Investigation
Current address: Laila Nutraceuticals R&D Centre, JRD Tata Industrial Estate, Kanur, Vijayawada, Andhra Pradesh, India.
Affiliation Leeds Institute of Medical Research, School of Medicine, Faculty of Medicine and Health, St James’s University Hospital, University of Leeds, Leeds, West Yorkshire, United Kingdom
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Clive S. McKimmie,
Roles Resources, Supervision
Affiliation Leeds Institute of Medical Research, School of Medicine, Faculty of Medicine and Health, St James’s University Hospital, University of Leeds, Leeds, West Yorkshire, United Kingdom
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Paul Targett-Adams,
Roles Funding acquisition, Resources
Current address: Sygnature Discovery, BioCity, Nottingham United Kingdom
Affiliation Pfizer UK, Sandwich, Kent, United Kingdom
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Jason R. Schnell,
Roles Formal analysis, Funding acquisition, Supervision, Writing – review & editing
Affiliation Department of Biochemistry, University of Oxford, Oxford, United Kingdom
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Graham P. Cook,
Roles Supervision, Writing – review & editing
Affiliation Leeds Institute of Medical Research, School of Medicine, Faculty of Medicine and Health, St James’s University Hospital, University of Leeds, Leeds, West Yorkshire, United Kingdom
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Stephen Evans,
Roles Investigation, Methodology, Resources, Supervision
Affiliation Faculty of Engineering and Physical Sciences, School of Physics and Astronomy, University of Leeds, Leeds, West Yorkshire, United Kingdom
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Wendy S. Barclay ,
Contributed equally to this work with: Wendy S. Barclay, Richard Foster
Roles Conceptualization, Data curation, Methodology, Resources, Supervision, Writing – review & editing
Affiliation Faculty of Medicine, Section of Virology, Imperial College, London, United Kingdom
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Richard Foster ,
Contributed equally to this work with: Wendy S. Barclay, Richard Foster
Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Resources, Software, Supervision, Validation, Visualization, Writing – review & editing
Affiliations Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, West Yorkshire, United Kingdom, School of Chemistry, Faculty of Mathematics and Physical Sciences, University of Leeds, Leeds, West Yorkshire, United Kingdom
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Stephen Griffin
Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing
* E-mail: s.d.c.griffin@leeds.ac.uk
Affiliations Leeds Institute of Medical Research, School of Medicine, Faculty of Medicine and Health, St James’s University Hospital, University of Leeds, Leeds, West Yorkshire, United Kingdom, Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, West Yorkshire, United Kingdom
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Site-directed M2 proton channel inhibitors enable synergistic combination therapy for rimantadine-resistant pandemic influenza
- Claire Scott,
- Jayakanth Kankanala,
- Toshana L. Foster,
- Daniel H. Goldhill,
- Peng Bao,
- Katie Simmons,
- Marieke Pingen,
- Matthew Bentham,
- Elizabeth Atkins,
- Eleni Loundras
![PLOS](/resource/img/logo-plos.png)
- Published: August 11, 2020
- https://doi.org/10.1371/journal.ppat.1008716
- See the preprint