Dissecting distinct proteolytic activities of FMDV L^pro implicates cleavage and degradation of RLR signaling proteins, not its deISGylase/DUB activity, in type I interferon suppression

• Linda J. Visser,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, The Netherlands

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• Chiara Aloise ,

  Contributed equally to this work with: Chiara Aloise, Kirby N. Swatek, Gisselle N. Medina, Karin M. Olek

  Roles Data curation, Formal analysis, Investigation, Visualization

  Affiliation Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, The Netherlands

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• Kirby N. Swatek ,

  Contributed equally to this work with: Chiara Aloise, Kirby N. Swatek, Gisselle N. Medina, Karin M. Olek

  Roles Data curation, Formal analysis, Investigation, Validation, Visualization, Writing – review & editing

  Affiliations Protein and Nucleic Acid Chemistry Division, Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom, Department of Molecular Machines and Signaling, Max Planck Institute of Biochemistry, Martinsried, Germany

  http://orcid.org/0000-0003-0634-3592

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• Gisselle N. Medina ,

  Contributed equally to this work with: Chiara Aloise, Kirby N. Swatek, Gisselle N. Medina, Karin M. Olek

  Roles Data curation, Formal analysis, Investigation, Validation, Visualization, Writing – review & editing

  Current address: GNM is at Kansas State University College of Veterinary Medicine, Manhattan, USA; HHR is at the Hubrecht Institute, Utrecht, The Netherlands; and MAL is at MSD Animal Health, Boxmeer, The Netherlands.

  Affiliation United States Department of Agriculture, Agricultural Research Service, Foreign Animal Disease Research Unit, Plum Island Animal Disease Center, Orient, New York, United States of America

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• Karin M. Olek ,

  Contributed equally to this work with: Chiara Aloise, Kirby N. Swatek, Gisselle N. Medina, Karin M. Olek

  Roles Data curation, Formal analysis, Investigation, Validation, Visualization, Writing – review & editing

  Affiliation Department of Medical Biochemistry, Max Perutz Labs, Vienna Biocenter, Medical University of Vienna, Vienna, Austria

  http://orcid.org/0000-0002-7234-9696

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• Huib H. Rabouw,

  Roles Data curation, Formal analysis, Investigation, Writing – review & editing

  Current address: GNM is at Kansas State University College of Veterinary Medicine, Manhattan, USA; HHR is at the Hubrecht Institute, Utrecht, The Netherlands; and MAL is at MSD Animal Health, Boxmeer, The Netherlands.

  Affiliation Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, The Netherlands

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• Raoul J. de Groot,

  Roles Conceptualization, Supervision, Validation, Writing – review & editing

  Affiliation Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, The Netherlands

  http://orcid.org/0000-0002-2207-9472

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• Martijn A. Langereis,

  Roles Conceptualization, Funding acquisition, Methodology, Supervision, Validation, Writing – review & editing

  Current address: GNM is at Kansas State University College of Veterinary Medicine, Manhattan, USA; HHR is at the Hubrecht Institute, Utrecht, The Netherlands; and MAL is at MSD Animal Health, Boxmeer, The Netherlands.

  Affiliation Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, The Netherlands

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• Teresa de los Santos,

  Roles Funding acquisition, Supervision, Validation, Writing – review & editing

  Affiliation United States Department of Agriculture, Agricultural Research Service, Foreign Animal Disease Research Unit, Plum Island Animal Disease Center, Orient, New York, United States of America

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• David Komander,

  Roles Funding acquisition, Supervision, Validation, Writing – review & editing

  Affiliations Protein and Nucleic Acid Chemistry Division, Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom, Ubiquitin Signaling Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia, Department of Medical Biology, The University of Melbourne, Melbourne, Australia

  http://orcid.org/0000-0002-8092-4320

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• Tim Skern,

  Roles Conceptualization, Funding acquisition, Supervision, Validation, Writing – original draft

  Affiliation Department of Medical Biochemistry, Max Perutz Labs, Vienna Biocenter, Medical University of Vienna, Vienna, Austria

  http://orcid.org/0000-0001-8865-5500

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• Frank J. M. van Kuppeveld

  Roles Conceptualization, Funding acquisition, Methodology, Project administration, Supervision, Validation, Visualization, Writing – original draft

  * E-mail: f.j.m.vankuppeveld@uu.nl

  Affiliation Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, The Netherlands

  http://orcid.org/0000-0001-5800-749X

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