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Open Access
Peer-reviewed
Research Article
Evolving MRSA: High-level β-lactam resistance in Staphylococcus aureus is associated with RNA Polymerase alterations and fine tuning of gene expression
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Viralkumar V. Panchal,
Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Validation, Visualization, Writing – original draft, Writing – review & editing
Affiliations Department of Molecular Biology and Biotechnology, University of Sheffield, Western Bank, Sheffield, United Kingdom, The Florey Institute for Host-Pathogen Interactions, University of Sheffield, Sheffield, United Kingdom
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Caitlin Griffiths,
Roles Investigation, Methodology
Affiliation Centre for Bacterial Cell Biology, Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom
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Hamed Mosaei,
Roles Investigation, Methodology, Writing – original draft
Affiliation Centre for Bacterial Cell Biology, Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom
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Bohdan Bilyk,
Roles Formal analysis, Investigation
Affiliations Department of Molecular Biology and Biotechnology, University of Sheffield, Western Bank, Sheffield, United Kingdom, The Florey Institute for Host-Pathogen Interactions, University of Sheffield, Sheffield, United Kingdom
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Joshua A. F. Sutton,
Roles Formal analysis, Investigation
Affiliations Department of Molecular Biology and Biotechnology, University of Sheffield, Western Bank, Sheffield, United Kingdom, The Florey Institute for Host-Pathogen Interactions, University of Sheffield, Sheffield, United Kingdom
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Oliver T. Carnell,
Roles Formal analysis, Investigation
Affiliations Department of Molecular Biology and Biotechnology, University of Sheffield, Western Bank, Sheffield, United Kingdom, The Florey Institute for Host-Pathogen Interactions, University of Sheffield, Sheffield, United Kingdom
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David P. Hornby,
Roles Formal analysis, Writing – original draft, Writing – review & editing
Affiliation Department of Molecular Biology and Biotechnology, University of Sheffield, Western Bank, Sheffield, United Kingdom
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Jeffrey Green,
Roles Conceptualization, Formal analysis, Writing – original draft, Writing – review & editing
Affiliation Department of Molecular Biology and Biotechnology, University of Sheffield, Western Bank, Sheffield, United Kingdom
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Jamie K. Hobbs,
Roles Supervision, Writing – review & editing
Affiliations The Florey Institute for Host-Pathogen Interactions, University of Sheffield, Sheffield, United Kingdom, Department of Physics and Astronomy, University of Sheffield, Sheffield, United Kingdom
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William L. Kelley,
Roles Formal analysis, Writing – original draft, Writing – review & editing
Affiliation Department of Microbiology and Molecular Medicine, University Hospital and Medical School of Geneva, Geneva, Switzerland
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Nikolay Zenkin,
Roles Conceptualization, Formal analysis, Funding acquisition, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing
Affiliation Centre for Bacterial Cell Biology, Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom
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Simon J. Foster
Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – original draft, Writing – review & editing
* E-mail: s.foster@sheffield.ac.uk
Affiliations Department of Molecular Biology and Biotechnology, University of Sheffield, Western Bank, Sheffield, United Kingdom, The Florey Institute for Host-Pathogen Interactions, University of Sheffield, Sheffield, United Kingdom
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Evolving MRSA: High-level β-lactam resistance in Staphylococcus aureus is associated with RNA Polymerase alterations and fine tuning of gene expression
- Viralkumar V. Panchal,
- Caitlin Griffiths,
- Hamed Mosaei,
- Bohdan Bilyk,
- Joshua A. F. Sutton,
- Oliver T. Carnell,
- David P. Hornby,
- Jeffrey Green,
- Jamie K. Hobbs,
- William L. Kelley
- Published: July 24, 2020
- https://doi.org/10.1371/journal.ppat.1008672