Mutant prion proteins increase calcium permeability of AMPA receptors, exacerbating excitotoxicity

Elsa Ghirardini; Elena Restelli; Raffaella Morini; Ilaria Bertani; Davide Ortolan; Fabio Perrucci; Davide Pozzi; Michela Matteoli; Roberto Chiesa

doi:10.1371/journal.ppat.1008654

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Open Access

Peer-reviewed

Research Article

Mutant prion proteins increase calcium permeability of AMPA receptors, exacerbating excitotoxicity

Elsa Ghirardini ,

Contributed equally to this work with: Elsa Ghirardini, Elena Restelli

Roles Investigation, Writing – original draft

Current address: Consiglio Nazionale delle Ricerche Institute of Neuroscience, Pisa, Italy

Affiliation Laboratory of Pharmacology and Brain Pathology, Humanitas Clinical and Research Center, Rozzano—Milan, Italy
⨯
Elena Restelli ,

Contributed equally to this work with: Elsa Ghirardini, Elena Restelli

Roles Investigation, Writing – review & editing

Affiliation Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy
⨯
Raffaella Morini,

Roles Investigation

Affiliation Laboratory of Pharmacology and Brain Pathology, Humanitas Clinical and Research Center, Rozzano—Milan, Italy
⨯
Ilaria Bertani,

Roles Investigation

Affiliation Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy
⨯
Davide Ortolan,

Roles Investigation

Current address: Unit on Ocular and Stem Cell Translational Research, National Eye Institute, NIH, Bethesda, Maryland, United States of America

Affiliation Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy
⨯
Fabio Perrucci,

Roles Investigation

Affiliation Laboratory of Pharmacology and Brain Pathology, Humanitas Clinical and Research Center, Rozzano—Milan, Italy

http://orcid.org/0000-0001-6810-471X

⨯
Davide Pozzi,

Roles Investigation

Affiliation Laboratory of Pharmacology and Brain Pathology, Humanitas Clinical and Research Center, Rozzano—Milan, Italy
⨯
Michela Matteoli ,

Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

* E-mail: michela.matteoli@hunimed.eu (MM); roberto.chiesa@marionegri.it (RC)

Affiliations Laboratory of Pharmacology and Brain Pathology, Humanitas Clinical and Research Center, Rozzano—Milan, Italy, Consiglio Nazionale delle Ricerche Institute of Neuroscience, Milan, Italy
⨯
Roberto Chiesa

Roles Conceptualization, Funding acquisition, Supervision, Writing – original draft, Writing – review & editing

* E-mail: michela.matteoli@hunimed.eu (MM); roberto.chiesa@marionegri.it (RC)

Affiliation Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy

http://orcid.org/0000-0002-3842-3733

⨯

Mutant prion proteins increase calcium permeability of AMPA receptors, exacerbating excitotoxicity

Elsa Ghirardini,
Elena Restelli,
Raffaella Morini,
Ilaria Bertani,
Davide Ortolan,
Fabio Perrucci,
Davide Pozzi,
Michela Matteoli,
Roberto Chiesa

Published: July 16, 2020
https://doi.org/10.1371/journal.ppat.1008654

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