System-wide biochemical analysis reveals ozonide antimalarials initially act by disrupting Plasmodium falciparum haemoglobin digestion

• Carlo Giannangelo ,

  Contributed equally to this work with: Carlo Giannangelo, Ghizal Siddiqui

  Roles Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia

  http://orcid.org/0000-0002-6654-7266

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• Ghizal Siddiqui ,

  Contributed equally to this work with: Carlo Giannangelo, Ghizal Siddiqui

  Roles Data curation, Formal analysis, Investigation, Methodology, Supervision, Visualization, Writing – review & editing

  Affiliation Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia

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• Amanda De Paoli,

  Roles Investigation, Methodology

  Affiliation Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia

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• Bethany M. Anderson,

  Roles Methodology

  Affiliations Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, Victoria, Australia

  http://orcid.org/0000-0002-1663-1099

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• Laura E. Edgington-Mitchell,

  Roles Methodology, Resources, Supervision, Writing – review & editing

  Affiliations Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, Victoria, Australia, Department of Maxillofacial Surgery, College of Dentistry, New York University, New York, New York, United States of America

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• Susan A. Charman,

  Roles Funding acquisition, Supervision, Writing – review & editing

  Affiliation Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia

  http://orcid.org/0000-0003-1753-8213

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• Darren J. Creek

  Roles Conceptualization, Data curation, Funding acquisition, Project administration, Resources, Software, Supervision, Writing – review & editing

  * E-mail: Darren.creek@monash.edu

  Affiliation Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia

  http://orcid.org/0000-0001-7497-7082

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