New live attenuated tuberculosis vaccine MTBVAC induces trained immunity and confers protection against experimental lethal pneumonia

• Raquel Tarancón ,

  Contributed equally to this work with: Raquel Tarancón, Jorge Domínguez-Andrés

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Writing – review & editing

  Affiliations Department of Microbiology, Faculty of Medicine, University of Zaragoza, Zaragoza, Spain, CIBERES and Research Network on Respiratory Diseases, Spanish Ministry of Health and Instituto de Salud Carlos III, Madrid, Spain

  http://orcid.org/0000-0002-3086-3013

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• Jorge Domínguez-Andrés ,

  Contributed equally to this work with: Raquel Tarancón, Jorge Domínguez-Andrés

  Roles Conceptualization, Investigation, Supervision, Writing – original draft

  * E-mail: jorge.dominguezandres@radboudumc.nl

  Affiliation Department of Internal Medicine and Radboud Center for Infectious diseases (RCI), Radboud University Nijmegen Medical Centre, Geert Grooteplein 8, Nijmegen, the Netherlands

  http://orcid.org/0000-0002-9091-1961

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• Santiago Uranga,

  Roles Conceptualization, Data curation, Formal analysis, Investigation

  Affiliations Department of Microbiology, Faculty of Medicine, University of Zaragoza, Zaragoza, Spain, CIBERES and Research Network on Respiratory Diseases, Spanish Ministry of Health and Instituto de Salud Carlos III, Madrid, Spain

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• Anaísa V. Ferreira,

  Roles Investigation, Writing – review & editing

  Affiliations Department of Internal Medicine and Radboud Center for Infectious diseases (RCI), Radboud University Nijmegen Medical Centre, Geert Grooteplein 8, Nijmegen, the Netherlands, Instituto de Ciências Biomédicas Abel Salazar (ICBAS), Universidade do Porto, Porto, Portugal

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• Laszlo A. Groh,

  Roles Investigation, Writing – review & editing

  Affiliation Department of Internal Medicine and Radboud Center for Infectious diseases (RCI), Radboud University Nijmegen Medical Centre, Geert Grooteplein 8, Nijmegen, the Netherlands

  ⨯
• Mirian Domenech,

  Roles Investigation

  Affiliations CIBERES and Research Network on Respiratory Diseases, Spanish Ministry of Health and Instituto de Salud Carlos III, Madrid, Spain, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Madrid, Spain

  http://orcid.org/0000-0002-0942-8180

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• Fernando González-Camacho,

  Roles Investigation

  Affiliations CIBERES and Research Network on Respiratory Diseases, Spanish Ministry of Health and Instituto de Salud Carlos III, Madrid, Spain, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Madrid, Spain

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• Niels P. Riksen,

  Roles Supervision

  Affiliation Department of Internal Medicine and Radboud Center for Infectious diseases (RCI), Radboud University Nijmegen Medical Centre, Geert Grooteplein 8, Nijmegen, the Netherlands

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• Nacho Aguilo,

  Roles Conceptualization, Investigation, Supervision, Writing – review & editing

  Affiliations Department of Microbiology, Faculty of Medicine, University of Zaragoza, Zaragoza, Spain, CIBERES and Research Network on Respiratory Diseases, Spanish Ministry of Health and Instituto de Salud Carlos III, Madrid, Spain

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• José Yuste,

  Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

  Affiliations CIBERES and Research Network on Respiratory Diseases, Spanish Ministry of Health and Instituto de Salud Carlos III, Madrid, Spain, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Madrid, Spain

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• Carlos Martín ,

  Roles Conceptualization, Funding acquisition, Investigation, Supervision, Writing – review & editing

  ¶‡ These authors joint senior authors on this work

  Affiliations Department of Microbiology, Faculty of Medicine, University of Zaragoza, Zaragoza, Spain, CIBERES and Research Network on Respiratory Diseases, Spanish Ministry of Health and Instituto de Salud Carlos III, Madrid, Spain, Servicio de Microbiología, Hospital Miguel Servet, ISS Aragón, Zaragoza, Spain

  http://orcid.org/0000-0003-2993-5478

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• Mihai G. Netea

  Roles Conceptualization, Investigation, Supervision, Writing – review & editing

  ¶‡ These authors joint senior authors on this work

  Affiliations Department of Internal Medicine and Radboud Center for Infectious diseases (RCI), Radboud University Nijmegen Medical Centre, Geert Grooteplein 8, Nijmegen, the Netherlands, Department for Genomics & Immunoregulation, Life and Medical Sciences Institute (LIMES), University of Bonn, Bonn, Germany, Human Genomics Laboratory, Craiova University of Medicine and Pharmacy, Craiova, Romania

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