Combination immunotherapy with anti-PD-L1 antibody and depletion of regulatory T cells during acute viral infections results in improved virus control but lethal immunopathology

• Paul David,

  Roles Data curation, Formal analysis, Methodology

  Affiliation Institute for Virology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany

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• Malgorzata Drabczyk-Pluta,

  Roles Data curation, Formal analysis, Methodology

  Affiliation Institute for Virology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany

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• Eva Pastille,

  Roles Data curation, Formal analysis, Methodology

  Affiliation Institute of Medical Microbiology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany

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• Torben Knuschke,

  Roles Data curation, Formal analysis, Methodology

  Affiliation Institute of Medical Microbiology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany

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• Tanja Werner,

  Roles Data curation, Formal analysis, Methodology

  Affiliation Institute for Virology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany

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• Nadine Honke,

  Roles Data curation, Formal analysis, Investigation

  Affiliation Department of Rheumatology, Hiller Research Center Rheumatology, University Hospital Düsseldorf, Germany

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• Dominik A. Megger,

  Roles Data curation, Formal analysis, Methodology, Validation, Writing – original draft

  Affiliation Medizinisches Proteom-Center, Ruhr-Universität Bochum, Bochum, Germany

  http://orcid.org/0000-0002-1058-7744

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• Ilseyar Akhmetzyanova,

  Roles Data curation, Formal analysis, Methodology

  Affiliations Institute for Virology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, Department of Pathology, Albert Einstein College of Medicine, New York, New York, United States of America

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• Namir Shaabani,

  Roles Data curation, Formal analysis, Methodology

  Affiliation Institute of Immunology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany

  http://orcid.org/0000-0003-3548-5899

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• Annette Eyking-Singer,

  Roles Data curation, Formal analysis, Methodology

  Affiliation Department of Gastroenterology and Hepatology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany

  http://orcid.org/0000-0003-3003-2006

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• Elke Cario,

  Roles Investigation, Methodology, Validation, Writing – original draft

  Affiliation Department of Gastroenterology and Hepatology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany

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• Olivia Kershaw,

  Roles Data curation, Investigation, Methodology, Validation

  Affiliation Department of Veterinary Medicine, Institute of Veterinary Pathology, Free University Berlin, Berlin, Germany

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• Achim D. Gruber,

  Roles Supervision, Validation, Visualization

  Affiliation Department of Veterinary Medicine, Institute of Veterinary Pathology, Free University Berlin, Berlin, Germany

  http://orcid.org/0000-0002-4502-0393

  ⨯
• Matthias Tenbusch,

  Roles Formal analysis, Methodology, Validation

  Affiliation Institute of Clinical and Molecular Virology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany

  http://orcid.org/0000-0003-3951-9056

  ⨯
• Kirsten K. Dietze,

  Roles Investigation, Methodology

  Affiliation Institute for Virology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany

  ⨯
• Mirko Trilling,

  Roles Conceptualization, Methodology, Supervision

  Affiliation Institute for Virology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany

  http://orcid.org/0000-0003-3659-3541

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• Jia Liu,

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation

  Affiliation Department of Infectious Diseases, Union Hospital of Tonji Medical College, Huazhong University of Science and Technology, Wuhan, China

  ⨯
• Dirk Schadendorf,

  Roles Investigation, Supervision, Validation

  Affiliation Department of Dermatology, Comprehensive Cancer Center, University Hospital Essen, Essen, Germany

  http://orcid.org/0000-0003-3524-7858

  ⨯
• Hendrik Streeck,

  Roles Supervision, Validation, Writing – review & editing

  Affiliation Institute for HIV Research, University Hospital Essen, University Duisburg-Essen, Essen, Germany

  http://orcid.org/0000-0002-0335-6390

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• Karl S. Lang,

  Roles Supervision, Validation

  Affiliation Institute of Immunology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany

  ⨯
• Youhua Xie,

  Roles Supervision, Validation

  Affiliation Key Lab of Molecular Virology, Shanghai Medical College, Fudan University, Shanghai, China

  ⨯
• Lisa Zimmer,

  Roles Formal analysis, Investigation, Validation, Writing – original draft, Writing – review & editing

  Affiliation Department of Dermatology, Comprehensive Cancer Center, University Hospital Essen, Essen, Germany

  ⨯
• Barbara Sitek,

  Roles Supervision, Validation, Visualization

  Affiliation Medizinisches Proteom-Center, Ruhr-Universität Bochum, Bochum, Germany

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• Annette Paschen,

  Roles Formal analysis, Investigation, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Dermatology, Comprehensive Cancer Center, University Hospital Essen, Essen, Germany

  ⨯
• Astrid M. Westendorf,

  Roles Investigation, Supervision, Validation, Writing – review & editing

  Affiliation Institute of Medical Microbiology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany

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• Ulf Dittmer,

  Roles Conceptualization, Funding acquisition, Investigation, Resources, Supervision, Validation, Writing – original draft, Writing – review & editing

  Affiliation Institute for Virology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany

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•  [ ... ],
• Gennadiy Zelinskyy

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: gennadiy.zelinskyy@uni-due.de

  Affiliation Institute for Virology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany

  http://orcid.org/0000-0001-6338-2382

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