PDGFRA defines the mesenchymal stem cell Kaposi’s sarcoma progenitors by enabling KSHV oncogenesis in an angiogenic environment

Julian Naipauer; Santas Rosario; Sachin Gupta; Courtney Premer; Omayra Méndez-Solís; Mariana Schlesinger; Virginia Ponzinibbio; Vaibhav Jain; Lauren Gay; Rolf Renne; Ho Lam Chan; Lluis Morey; Daria Salyakina; Martin Abba; Sion Williams; Joshua M. Hare; Pascal J. Goldschmidt-Clermont; Enrique A. Mesri

doi:10.1371/journal.ppat.1008221

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Open Access

Peer-reviewed

Research Article

PDGFRA defines the mesenchymal stem cell Kaposi’s sarcoma progenitors by enabling KSHV oncogenesis in an angiogenic environment

Julian Naipauer,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Resources, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliations Tumor Biology Program, Sylvester Comprehensive Cancer Center and Miami Center for AIDS Research, Department of Microbiology and Immunology, Miami, Florida, United States of America, UM-CFAR/ Sylvester CCC Argentina Consortium for Research and Training in Virally induced AIDS-Malignancies, Miami, Florida, United States of America
⨯
Santas Rosario,

Roles Formal analysis, Investigation, Methodology, Writing – review & editing

Affiliation Tumor Biology Program, Sylvester Comprehensive Cancer Center and Miami Center for AIDS Research, Department of Microbiology and Immunology, Miami, Florida, United States of America
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Sachin Gupta,

Roles Conceptualization, Formal analysis, Investigation, Methodology

Affiliation Tumor Biology Program, Sylvester Comprehensive Cancer Center and Miami Center for AIDS Research, Department of Microbiology and Immunology, Miami, Florida, United States of America
⨯
Courtney Premer,

Roles Resources, Writing – review & editing

Affiliation Interdisciplinary Stem Cell Institute; University of Miami Miller School of Medicine, Miami, Florida, United States of America

http://orcid.org/0000-0001-6175-0049

⨯
Omayra Méndez-Solís,

Roles Investigation, Methodology, Writing – review & editing

Affiliation Tumor Biology Program, Sylvester Comprehensive Cancer Center and Miami Center for AIDS Research, Department of Microbiology and Immunology, Miami, Florida, United States of America
⨯
Mariana Schlesinger,

Roles Investigation, Methodology, Writing – review & editing

Affiliation Tumor Biology Program, Sylvester Comprehensive Cancer Center and Miami Center for AIDS Research, Department of Microbiology and Immunology, Miami, Florida, United States of America
⨯
Virginia Ponzinibbio,

Roles Formal analysis, Investigation, Methodology

Affiliations Tumor Biology Program, Sylvester Comprehensive Cancer Center and Miami Center for AIDS Research, Department of Microbiology and Immunology, Miami, Florida, United States of America, UM-CFAR/ Sylvester CCC Argentina Consortium for Research and Training in Virally induced AIDS-Malignancies, Miami, Florida, United States of America
⨯
Vaibhav Jain,

Roles Formal analysis, Investigation, Methodology, Writing – review & editing

Affiliation Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, Florida, United States of America
⨯
Lauren Gay,

Roles Data curation, Methodology

Affiliation Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, Florida, United States of America
⨯
Rolf Renne,

Roles Conceptualization, Data curation, Funding acquisition, Investigation, Resources, Supervision, Writing – review & editing

Affiliation Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, Florida, United States of America
⨯
Ho Lam Chan,

Roles Data curation, Formal analysis, Methodology, Writing – review & editing

Affiliation Department of Human Genetics, University of Miami Miller School of Medicine, Sylvester Comprehensive Cancer Center, Miami, Florida, United States of America
⨯
Lluis Morey,

Roles Data curation, Formal analysis, Supervision, Writing – review & editing

Affiliation Department of Human Genetics, University of Miami Miller School of Medicine, Sylvester Comprehensive Cancer Center, Miami, Florida, United States of America
⨯
Daria Salyakina,

Roles Data curation, Formal analysis, Methodology, Visualization

Affiliation Tumor Biology Program, Sylvester Comprehensive Cancer Center and Miami Center for AIDS Research, Department of Microbiology and Immunology, Miami, Florida, United States of America

http://orcid.org/0000-0003-3283-3691

⨯
Martin Abba,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – review & editing

Affiliations UM-CFAR/ Sylvester CCC Argentina Consortium for Research and Training in Virally induced AIDS-Malignancies, Miami, Florida, United States of America, Centro de Investigaciones Inmunológicas Básicas y Aplicadas, Facultad de Ciencias Médicas, Universidad Nacional de La Plata, La Plata, Argentina
⨯
Sion Williams,

Roles Data curation, Methodology

Affiliations UM-CFAR/ Sylvester CCC Argentina Consortium for Research and Training in Virally induced AIDS-Malignancies, Miami, Florida, United States of America, Neurology Basic Science Division, Sylvester Comprehensive Cancer Center; University of Miami Miller School of Medicine, Miami, Florida, United States of America
⨯
Joshua M. Hare,

Roles Conceptualization, Funding acquisition, Investigation, Resources, Supervision, Writing – review & editing

Affiliation Interdisciplinary Stem Cell Institute; University of Miami Miller School of Medicine, Miami, Florida, United States of America
⨯
Pascal J. Goldschmidt-Clermont,

Roles Conceptualization, Funding acquisition, Investigation, Resources, Supervision

Affiliation Tumor Biology Program, Sylvester Comprehensive Cancer Center and Miami Center for AIDS Research, Department of Microbiology and Immunology, Miami, Florida, United States of America

http://orcid.org/0000-0003-2915-0101

⨯
[ ... ],
Enrique A. Mesri

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

* E-mail: emesri@med.miami.edu

Affiliations Tumor Biology Program, Sylvester Comprehensive Cancer Center and Miami Center for AIDS Research, Department of Microbiology and Immunology, Miami, Florida, United States of America, UM-CFAR/ Sylvester CCC Argentina Consortium for Research and Training in Virally induced AIDS-Malignancies, Miami, Florida, United States of America

http://orcid.org/0000-0003-4061-9564

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PDGFRA defines the mesenchymal stem cell Kaposi’s sarcoma progenitors by enabling KSHV oncogenesis in an angiogenic environment

Julian Naipauer,
Santas Rosario,
Sachin Gupta,
Courtney Premer,
Omayra Méndez-Solís,
Mariana Schlesinger,
Virginia Ponzinibbio,
Vaibhav Jain,
Lauren Gay,
Rolf Renne

Published: December 27, 2019
https://doi.org/10.1371/journal.ppat.1008221

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Mesenchymal stem cells
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Gene expression
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Cancers and neoplasms
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Kaposi's sarcoma-associated herpesvirus
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Carcinogenesis
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Kaposi sarcoma
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Malignant tumors
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Oncogenic signaling
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