Proteasomal inhibition triggers viral oncoprotein degradation via autophagy-lysosomal pathway

Chandrima Gain; Samaresh Malik; Shaoni Bhattacharjee; Arijit Ghosh; Erle S. Robertson; Benu Brata Das; Abhik Saha

doi:10.1371/journal.ppat.1008105

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Open Access

Peer-reviewed

Research Article

Proteasomal inhibition triggers viral oncoprotein degradation via autophagy-lysosomal pathway

Chandrima Gain,

Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft

Affiliation Department of Life Sciences, Presidency University, West Bengal, India
⨯
Samaresh Malik,

Roles Data curation, Formal analysis, Methodology, Validation

Affiliation Department of Life Sciences, Presidency University, West Bengal, India

http://orcid.org/0000-0003-1046-6624

⨯
Shaoni Bhattacharjee,

Roles Data curation, Formal analysis, Investigation, Methodology

Affiliation Department of Life Sciences, Presidency University, West Bengal, India
⨯
Arijit Ghosh,

Roles Data curation, Formal analysis, Methodology

Affiliation Laboratory of Molecular Biology, School of Biological Sciences, Indian Association for the Cultivation of Science, Jadavpur, Kolkata, India

http://orcid.org/0000-0002-6837-2738

⨯
Erle S. Robertson,

Roles Resources, Software

Affiliation Department of Otorhinolaryngology Head and Neck Surgery, and the Tumor Virology Program, Abramson Comprehensive Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Benu Brata Das,

Roles Formal analysis, Methodology, Resources

Affiliation Laboratory of Molecular Biology, School of Biological Sciences, Indian Association for the Cultivation of Science, Jadavpur, Kolkata, India

http://orcid.org/0000-0003-2519-7105

⨯
Abhik Saha

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: abhik.dbs@presiuniv.ac.in

Affiliation Department of Life Sciences, Presidency University, West Bengal, India

http://orcid.org/0000-0001-7390-4578

⨯

Proteasomal inhibition triggers viral oncoprotein degradation via autophagy-lysosomal pathway

Chandrima Gain,
Samaresh Malik,
Shaoni Bhattacharjee,
Arijit Ghosh,
Erle S. Robertson,
Benu Brata Das,
Abhik Saha

Published: February 24, 2020
https://doi.org/10.1371/journal.ppat.1008105
See the preprint

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Autophagic cell death
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Transfection
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B cells
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Proteasomes
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Proteasome inhibitors
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