Emodepside has sex-dependent immobilizing effects on adult Brugia malayi due to a differentially spliced binding pocket in the RCK1 region of the SLO-1 K channel

• Sudhanva S. Kashyap ,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  ¶‡ SSK and SV are joint first authors on this work.

  Affiliation Department of Biomedical Sciences, Iowa State University, Ames, Iowa, United States of America

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• Saurabh Verma ,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Supervision, Writing – original draft, Writing – review & editing

  ¶‡ SSK and SV are joint first authors on this work.

  Affiliation Department of Biomedical Sciences, Iowa State University, Ames, Iowa, United States of America

  http://orcid.org/0000-0003-1417-0986

  ⨯
• Denis Voronin,

  Roles Resources, Writing – review & editing

  Affiliation Laboratory of Molecular Parasitology, Lindsley F. Kimball Research Institute, New York Blood Center, New York, New York, United States of America

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• Sara Lustigman,

  Roles Resources, Supervision, Writing – review & editing

  Affiliation Laboratory of Molecular Parasitology, Lindsley F. Kimball Research Institute, New York Blood Center, New York, New York, United States of America

  ⨯
• Daniel Kulke,

  Roles Conceptualization, Methodology, Resources, Writing – review & editing

  Affiliation Bayer Animal Health GmbH, Drug Discovery and External Innovation, Leverkusen, Germany

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• Alan P. Robertson,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Supervision, Writing – review & editing

  Affiliation Department of Biomedical Sciences, Iowa State University, Ames, Iowa, United States of America

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• Richard J. Martin

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: rjmartin@iastate.edu

  Affiliation Department of Biomedical Sciences, Iowa State University, Ames, Iowa, United States of America

  http://orcid.org/0000-0003-2422-1847

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