Neutralization-guided design of HIV-1 envelope trimers with high affinity for the unmutated common ancestor of CH235 lineage CD4bs broadly neutralizing antibodies

• Celia C. LaBranche,

  Roles Conceptualization, Data curation, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Department of Surgery, Duke University Medical Center, Durham, NC, United States of America

  http://orcid.org/0000-0002-6653-6655

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• Rory Henderson,

  Roles Investigation, Methodology

  Affiliation Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC, United States of America

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• Allen Hsu,

  Roles Methodology

  Affiliation Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC, United States of America

  http://orcid.org/0000-0003-2065-3802

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• Shay Behrens,

  Roles Data curation, Investigation

  Affiliation Department of Surgery, Duke University Medical Center, Durham, NC, United States of America

  http://orcid.org/0000-0001-8676-2345

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• Xuejun Chen,

  Roles Investigation, Resources

  Affiliation Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

  http://orcid.org/0000-0001-9192-0440

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• Tongqing Zhou,

  Roles Investigation, Resources

  Affiliation Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

  http://orcid.org/0000-0002-3935-4637

  ⨯
• Kevin Wiehe,

  Roles Investigation, Methodology

  Affiliations Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC, United States of America, Department of Medicine, Duke University Medical Center, Durham, NC, United States of America

  ⨯
• Kevin O. Saunders,

  Roles Investigation, Methodology, Resources, Writing – original draft, Writing – review & editing

  Affiliations Department of Surgery, Duke University Medical Center, Durham, NC, United States of America, Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC, United States of America

  http://orcid.org/0000-0001-7399-7954

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• S. Munir Alam,

  Roles Investigation, Methodology

  Affiliations Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC, United States of America, Department of Medicine, Duke University Medical Center, Durham, NC, United States of America

  ⨯
• Mattia Bonsignori,

  Roles Resources

  Affiliations Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC, United States of America, Department of Medicine, Duke University Medical Center, Durham, NC, United States of America

  http://orcid.org/0000-0003-2973-2101

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• Mario J. Borgnia,

  Roles Supervision

  Affiliation Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC, United States of America

  http://orcid.org/0000-0001-9159-1413

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• Quentin J. Sattentau,

  Roles Conceptualization, Writing – review & editing

  Affiliation The Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom

  http://orcid.org/0000-0001-7170-1937

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• Amanda Eaton,

  Roles Data curation, Project administration, Supervision

  Affiliation Department of Surgery, Duke University Medical Center, Durham, NC, United States of America

  ⨯
• Kelli Greene,

  Roles Project administration, Supervision

  Affiliation Department of Surgery, Duke University Medical Center, Durham, NC, United States of America

  ⨯
• Hongmei Gao,

  Roles Project administration, Supervision

  Affiliation Department of Surgery, Duke University Medical Center, Durham, NC, United States of America

  http://orcid.org/0000-0002-2468-8589

  ⨯
• Hua-Xin Liao,

  Roles Methodology, Resources

  Affiliations Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC, United States of America, Department of Medicine, Duke University Medical Center, Durham, NC, United States of America

  ⨯
• Wilton B. Williams,

  Roles Methodology, Resources

  Affiliations Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC, United States of America, Department of Medicine, Duke University Medical Center, Durham, NC, United States of America

  ⨯
• James Peacock,

  Roles Resources, Supervision

  Affiliations Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC, United States of America, Department of Medicine, Duke University Medical Center, Durham, NC, United States of America

  ⨯
• Haili Tang,

  Roles Investigation, Methodology, Resources

  Affiliation Department of Surgery, Duke University Medical Center, Durham, NC, United States of America

  ⨯
• Lautaro G. Perez,

  Roles Investigation, Methodology

  Affiliation Department of Surgery, Duke University Medical Center, Durham, NC, United States of America

  ⨯
• Robert J. Edwards,

  Roles Visualization, Writing – review & editing

  Affiliations Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC, United States of America, Department of Medicine, Duke University Medical Center, Durham, NC, United States of America

  http://orcid.org/0000-0003-4446-1194

  ⨯
• Thomas B. Kepler,

  Roles Investigation, Methodology

  Affiliation Department of Microbiology, Boston University School of Medicine, Boston, MA, United States of America

  http://orcid.org/0000-0002-1383-6865

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• Bette T. Korber,

  Roles Investigation, Methodology

  Affiliation Los Alamos National Laboratory, Theoretical Biology & Biophysics, Los Alamos, NM, United States of America

  ⨯
• Peter D. Kwong,

  Roles Methodology, Resources

  Affiliation Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

  ⨯
• John R. Mascola,

  Roles Funding acquisition, Methodology, Resources

  Affiliation Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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• Priyamvada Acharya,

  Roles Data curation, Funding acquisition, Investigation, Methodology, Supervision, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Department of Surgery, Duke University Medical Center, Durham, NC, United States of America, Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC, United States of America

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• Barton F. Haynes,

  Roles Conceptualization, Funding acquisition, Investigation, Methodology, Resources, Writing – review & editing

  Affiliations Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC, United States of America, Department of Medicine, Duke University Medical Center, Durham, NC, United States of America

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•  [ ... ],
• David C. Montefiori

  Roles Conceptualization, Funding acquisition, Investigation, Methodology, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: david.montefiori@duke.edu

  Affiliations Department of Surgery, Duke University Medical Center, Durham, NC, United States of America, Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC, United States of America

  http://orcid.org/0000-0003-0856-6319

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