KSHV-encoded LANA protects the cellular replication machinery from hypoxia induced degradation

Rajnish Kumar Singh; Zachary L. Lamplugh; Fengchao Lang; Yan Yuan; Paul Lieberman; Jianxin You; Erle S. Robertson

doi:10.1371/journal.ppat.1008025

Loading metrics

Open Access

Peer-reviewed

Research Article

KSHV-encoded LANA protects the cellular replication machinery from hypoxia induced degradation

Rajnish Kumar Singh,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Department of Otorhinolaryngology-Head and Neck surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
⨯
Zachary L. Lamplugh,

Roles Data curation, Investigation, Methodology, Validation

Affiliation Department of Otorhinolaryngology-Head and Neck surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
⨯
Fengchao Lang,

Roles Data curation, Formal analysis, Investigation, Methodology, Validation

Affiliation Department of Otorhinolaryngology-Head and Neck surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
⨯
Yan Yuan,

Roles Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

Affiliation Department of Microbiology, Levy Building, School of Dental Medicine, University of Pennsylvania, Philadelphia, United States of America
⨯
Paul Lieberman,

Roles Data curation, Formal analysis, Investigation, Writing – review & editing

Affiliation Program in Gene Regulation, The Wistar Institute, Philadelphia, United States of America
⨯
Jianxin You,

Roles Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

Affiliation Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
⨯
Erle S. Robertson

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Project administration, Resources, Software, Supervision, Writing – original draft, Writing – review & editing

* E-mail: erle@pennmedicine.upenn.edu.

Affiliation Department of Otorhinolaryngology-Head and Neck surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America

http://orcid.org/0000-0002-6088-2979

⨯

KSHV-encoded LANA protects the cellular replication machinery from hypoxia induced degradation

Rajnish Kumar Singh,
Zachary L. Lamplugh,
Fengchao Lang,
Yan Yuan,
Paul Lieberman,
Jianxin You,
Erle S. Robertson

Published: September 3, 2019
https://doi.org/10.1371/journal.ppat.1008025

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Hypoxia
Is the Subject Area "Hypoxia" applicable to this article?

Thanks for your feedback.
DNA replication
Is the Subject Area "DNA replication" applicable to this article?

Thanks for your feedback.
Aquatic hypoxia
Is the Subject Area "Aquatic hypoxia" applicable to this article?

Thanks for your feedback.
DNA-binding proteins
Is the Subject Area "DNA-binding proteins" applicable to this article?

Thanks for your feedback.
Viral replication
Is the Subject Area "Viral replication" applicable to this article?

Thanks for your feedback.
Cyclins
Is the Subject Area "Cyclins" applicable to this article?

Thanks for your feedback.
Cell cycle and cell division
Is the Subject Area "Cell cycle and cell division" applicable to this article?

Thanks for your feedback.
Kaposi's sarcoma-associated herpesvirus
Is the Subject Area "Kaposi's sarcoma-associated herpesvirus" applicable to this article?

Thanks for your feedback.