Gasdermin-D and Caspase-7 are the key Caspase-1/8 substrates downstream of the NAIP5/NLRC4 inflammasome required for restriction of Legionella pneumophila

• Augusto V. Gonçalves ,

  Contributed equally to this work with: Augusto V. Gonçalves, Shally R. Margolis

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Cell Biology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil

  ⨯
• Shally R. Margolis ,

  Contributed equally to this work with: Augusto V. Gonçalves, Shally R. Margolis

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – review & editing

  Affiliation Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, and Cancer Research Laboratory, University of California, Berkeley, California, United States of America

  http://orcid.org/0000-0003-3537-1672

  ⨯
• Gustavo F. S. Quirino,

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – review & editing

  Affiliation Department of Cell Biology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil

  http://orcid.org/0000-0002-3995-6259

  ⨯
• Danielle P. A. Mascarenhas,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – review & editing

  Affiliation Department of Cell Biology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil

  ⨯
• Isabella Rauch,

  Roles Conceptualization, Data curation, Investigation, Methodology, Writing – review & editing

  Current address: Department of Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, OR, United States of America

  Affiliation Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, and Cancer Research Laboratory, University of California, Berkeley, California, United States of America

  http://orcid.org/0000-0003-1897-5693

  ⨯
• Randilea D. Nichols,

  Roles Investigation, Methodology

  Current address: Department of Microbiology, Immunology, Molecular Genetics, University of California, Los Angeles, Los Angeles, CA, United States of America

  Affiliation Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, and Cancer Research Laboratory, University of California, Berkeley, California, United States of America

  http://orcid.org/0000-0002-3976-0037

  ⨯
• Eduard Ansaldo,

  Roles Conceptualization

  Affiliation Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, and Cancer Research Laboratory, University of California, Berkeley, California, United States of America

  http://orcid.org/0000-0002-7128-3373

  ⨯
• Mary F. Fontana,

  Roles Conceptualization

  Current address: Department of Immunology, University of Washington School of Medicine, Seattle, WA, United States of America

  Affiliation Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, and Cancer Research Laboratory, University of California, Berkeley, California, United States of America

  ⨯
• Russell E. Vance ,

  Roles Conceptualization, Data curation, Funding acquisition, Investigation, Project administration, Resources, Supervision, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: rvance@berkeley.edu (REV); dszamboni@fmrp.usp.br (DSZ)

  Affiliations Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, and Cancer Research Laboratory, University of California, Berkeley, California, United States of America, Howard Hughes Medical Institute, University of California, Berkeley, California, United States of America

  http://orcid.org/0000-0002-6686-3912

  ⨯
• Dario S. Zamboni

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Project administration, Resources, Supervision, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: rvance@berkeley.edu (REV); dszamboni@fmrp.usp.br (DSZ)

  Affiliation Department of Cell Biology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil

  http://orcid.org/0000-0002-7856-7512

  ⨯