Blowing epithelial cell bubbles with GumB: ShlA-family pore-forming toxins induce blebbing and rapid cellular death in corneal epithelial cells

• Kimberly M. Brothers ,

  Contributed equally to this work with: Kimberly M. Brothers, Jake D. Callaghan

  Roles Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliations Department of Ophthalmology, University of Pittsburgh, Pittsburgh, PA United States of America, Charles T. Campbell Laboratory of Ophthalmic Microbiology

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• Jake D. Callaghan ,

  Contributed equally to this work with: Kimberly M. Brothers, Jake D. Callaghan

  Roles Investigation, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Department of Ophthalmology, University of Pittsburgh, Pittsburgh, PA United States of America, Charles T. Campbell Laboratory of Ophthalmic Microbiology

  ⨯
• Nicholas A. Stella,

  Roles Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliations Department of Ophthalmology, University of Pittsburgh, Pittsburgh, PA United States of America, Charles T. Campbell Laboratory of Ophthalmic Microbiology

  ⨯
• Julianna M. Bachinsky,

  Roles Data curation, Investigation, Writing – review & editing

  Affiliations Department of Ophthalmology, University of Pittsburgh, Pittsburgh, PA United States of America, Charles T. Campbell Laboratory of Ophthalmic Microbiology

  http://orcid.org/0000-0001-6400-9520

  ⨯
• Mohammed AlHigaylan,

  Roles Data curation, Formal analysis, Methodology, Visualization

  Affiliations Department of Ophthalmology, University of Pittsburgh, Pittsburgh, PA United States of America, Charles T. Campbell Laboratory of Ophthalmic Microbiology

  http://orcid.org/0000-0001-6990-7565

  ⨯
• Kara L. Lehner,

  Roles Data curation, Methodology, Validation, Visualization

  Affiliations Department of Ophthalmology, University of Pittsburgh, Pittsburgh, PA United States of America, Charles T. Campbell Laboratory of Ophthalmic Microbiology

  ⨯
• Jonathan M. Franks,

  Roles Methodology, Writing – original draft, Writing – review & editing

  Affiliation Center for Biological Imaging, University of Pittsburgh, Pittsburgh, PA United States of America

  http://orcid.org/0000-0002-5758-185X

  ⨯
• Kira L. Lathrop,

  Roles Methodology, Software, Supervision, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Ophthalmology, University of Pittsburgh, Pittsburgh, PA United States of America

  ⨯
• Elliot Collins,

  Roles Data curation, Methodology, Writing – original draft

  Affiliation Department of Natural Sciences and Mathematics, West Liberty University, West Liberty, WV United States of America

  ⨯
• Deanna M. Schmitt,

  Roles Data curation, Investigation, Methodology, Writing – original draft

  Affiliation Department of Natural Sciences and Mathematics, West Liberty University, West Liberty, WV United States of America

  http://orcid.org/0000-0001-6644-9124

  ⨯
• Joseph Horzempa,

  Roles Conceptualization, Funding acquisition, Methodology, Resources, Supervision, Writing – original draft, Writing – review & editing

  Affiliation Department of Natural Sciences and Mathematics, West Liberty University, West Liberty, WV United States of America

  http://orcid.org/0000-0003-0867-5099

  ⨯
• Robert M. Q. Shanks

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Resources, Supervision, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: shanksrm@upmc.edu

  Affiliations Department of Ophthalmology, University of Pittsburgh, Pittsburgh, PA United States of America, Charles T. Campbell Laboratory of Ophthalmic Microbiology

  http://orcid.org/0000-0002-7699-5396

  ⨯