A streptococcal Fic domain-containing protein disrupts blood-brain barrier integrity by activating moesin in endothelial cells

• Zhe Ma ,

  Contributed equally to this work with: Zhe Ma, Jie Peng

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft

  Affiliations MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, Jiangsu, China, Division of Infectious Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Microbiology, Harvard Medical School, Boston, Massachusetts, United States of America, Ministry of Agriculture Key Laboratory of Animal Bacteriology, Nanjing, Jiangsu, China, Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, Jiangsu, China

  http://orcid.org/0000-0002-5212-5759

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• Jie Peng ,

  Contributed equally to this work with: Zhe Ma, Jie Peng

  Roles Data curation, Investigation, Methodology, Validation, Writing – original draft

  Affiliation MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, Jiangsu, China

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• Dandan Yu,

  Roles Data curation, Investigation, Methodology, Validation, Visualization

  Affiliation MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, Jiangsu, China

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• Joseph S. Park,

  Roles Conceptualization, Data curation, Methodology, Software, Writing – review & editing

  Affiliations Division of Infectious Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Microbiology, Harvard Medical School, Boston, Massachusetts, United States of America, Howard Hughes Medical Institute, Boston, Massachusetts, United States of America

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• Huixing Lin,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Supervision

  Affiliations MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, Jiangsu, China, Ministry of Agriculture Key Laboratory of Animal Bacteriology, Nanjing, Jiangsu, China, Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, Jiangsu, China

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• Bin Xu,

  Roles Data curation, Investigation, Methodology, Resources

  Affiliation MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, Jiangsu, China

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• Chengping Lu,

  Roles Conceptualization, Investigation, Methodology, Project administration, Supervision

  Affiliation MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, Jiangsu, China

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• Hongjie Fan ,

  Roles Conceptualization, Data curation, Funding acquisition, Investigation, Project administration, Supervision, Writing – original draft

  * E-mail: fhj@njau.edu.cn (HF); mwaldor@research.bwh.harvard.edu (MKW)

  Affiliations MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, Jiangsu, China, Ministry of Agriculture Key Laboratory of Animal Bacteriology, Nanjing, Jiangsu, China, Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, Jiangsu, China

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• Matthew K. Waldor

  Roles Conceptualization, Data curation, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Writing – original draft, Writing – review & editing

  * E-mail: fhj@njau.edu.cn (HF); mwaldor@research.bwh.harvard.edu (MKW)

  Affiliations Division of Infectious Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Microbiology, Harvard Medical School, Boston, Massachusetts, United States of America, Howard Hughes Medical Institute, Boston, Massachusetts, United States of America

  http://orcid.org/0000-0003-1843-7000

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