Viral RNA-dependent RNA polymerase mutants display an altered mutation spectrum resulting in attenuation in both mosquito and vertebrate hosts

• K. Lane Warmbrod,

  Roles Investigation, Writing – original draft

  Affiliation Department of Pathology, University of Texas Medical Branch, Galveston, Texas, United States of America

  http://orcid.org/0000-0003-4326-7541

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• Edward I. Patterson,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliation Department of Pathology, University of Texas Medical Branch, Galveston, Texas, United States of America

  http://orcid.org/0000-0003-3465-0848

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• Tiffany F. Kautz,

  Roles Formal analysis, Investigation, Writing – original draft, Writing – review & editing

  Current address: Departments of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas, United States of America

  Affiliation Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, United States of America

  http://orcid.org/0000-0001-7680-4708

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• Adam Stanton,

  Roles Formal analysis, Software

  Affiliation School of Computing and Mathematics, University of Keele, Keele, United Kingdom

  http://orcid.org/0000-0003-3865-2381

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• Dedeke Rockx-Brouwer,

  Roles Investigation

  Current address: Molecular Biology and Immunology, Intravacc, Bilthoven, Netherlands.

  Affiliation Department of Pathology, University of Texas Medical Branch, Galveston, Texas, United States of America

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• Birte K. Kalveram,

  Roles Investigation, Writing – review & editing

  Affiliation Department of Pathology, University of Texas Medical Branch, Galveston, Texas, United States of America

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• Kamil Khanipov,

  Roles Data curation, Formal analysis, Software

  Affiliation Sealy Center for Structural Biology and Molecular Biophysics, Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas, United States of America

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• Saravanan Thangamani,

  Roles Project administration

  Current address: Department of Microbiology and Immunology, SUNY Center for Environmental Health and Medicine, Institute for Global Health and Translational Science, SUNY Upstate Medical University, Syracuse NY 13210

  Affiliation Department of Pathology, University of Texas Medical Branch, Galveston, Texas, United States of America

  http://orcid.org/0000-0002-4269-5993

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• Yuriy Fofanov,

  Roles Formal analysis, Software

  Affiliation Sealy Center for Structural Biology and Molecular Biophysics, Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas, United States of America

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• Naomi L. Forrester

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Writing – review & editing

  * E-mail: n.forrester-soto@keele.ac.uk

  Current address: School of Life Sciences, University of Keele, Keele, United Kingdom

  Affiliation Department of Pathology, University of Texas Medical Branch, Galveston, Texas, United States of America

  http://orcid.org/0000-0001-8892-5216

  ⨯