TLR4 signaling improves PD-1 blockade therapy during chronic viral infection

Yidan Wang; Young Rock Chung; Simon Eitzinger; Nicole Palacio; Shana Gregory; Mitra Bhattacharyya; Pablo Penaloza-MacMaster

doi:10.1371/journal.ppat.1007583

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Open Access

Peer-reviewed

Research Article

TLR4 signaling improves PD-1 blockade therapy during chronic viral infection

Yidan Wang,

Roles Investigation

Affiliation Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States of America
⨯
Young Rock Chung,

Roles Investigation

Affiliation Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States of America
⨯
Simon Eitzinger,

Roles Investigation

Affiliation Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States of America

http://orcid.org/0000-0002-2215-4348

⨯
Nicole Palacio,

Roles Investigation

Affiliation Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States of America
⨯
Shana Gregory,

Roles Investigation

Affiliation Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States of America
⨯
Mitra Bhattacharyya,

Roles Investigation

Affiliation Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States of America
⨯
Pablo Penaloza-MacMaster

Roles Conceptualization, Investigation, Project administration, Supervision, Writing – original draft, Writing – review & editing

* E-mail: ppm@northwestern.edu

Affiliation Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States of America

http://orcid.org/0000-0001-9986-4906

⨯

TLR4 signaling improves PD-1 blockade therapy during chronic viral infection

Yidan Wang,
Young Rock Chung,
Simon Eitzinger,
Nicole Palacio,
Shana Gregory,
Mitra Bhattacharyya,
Pablo Penaloza-MacMaster

Published: February 6, 2019
https://doi.org/10.1371/journal.ppat.1007583

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