PIKfyve/Fab1 is required for efficient V-ATPase and hydrolase delivery to phagosomes, phagosomal killing, and restriction of Legionella infection

• Catherine M. Buckley,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Current address: Sick kids hospital for Sick Children,Toronto, Canada.

  Affiliations Centre for Membrane Interactions and Dynamics, Department of Biomedical Sciences, University of Sheffield, Firth Court, Western Bank, Sheffield, United Kingdom, Bateson Centre, University of Sheffield, Firth Court, Western Bank, Sheffield, United Kingdom

  http://orcid.org/0000-0003-2105-0456

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• Victoria L. Heath,

  Roles Conceptualization, Investigation, Methodology, Writing – review & editing

  Affiliation Institute of Cardiovascular Sciences, Institute for Biomedical Research, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham, United Kingdom

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• Aurélie Guého,

  Roles Investigation, Methodology

  Affiliation Department of Biochemistry, Faculty of Sciences, University of Geneva, Geneva, Switzerland

  http://orcid.org/0000-0002-8992-8686

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• Cristina Bosmani,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliation Department of Biochemistry, Faculty of Sciences, University of Geneva, Geneva, Switzerland

  http://orcid.org/0000-0001-9981-5899

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• Paulina Knobloch,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliation Institute of Medical Microbiology, University of Zürich, Zürich, Switzerland

  http://orcid.org/0000-0001-8057-153X

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• Phumzile Sikakana,

  Roles Investigation

  Affiliation Centre for Membrane Interactions and Dynamics, Department of Biomedical Sciences, University of Sheffield, Firth Court, Western Bank, Sheffield, United Kingdom

  http://orcid.org/0000-0002-3773-5655

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• Nicolas Personnic,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliation Institute of Medical Microbiology, University of Zürich, Zürich, Switzerland

  http://orcid.org/0000-0001-8995-4617

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• Stephen K. Dove,

  Roles Conceptualization, Funding acquisition, Project administration, Supervision

  Affiliation School of Biosciences, University of Birmingham, Edgbaston, Birmingham, United Kingdom

  http://orcid.org/0000-0003-2821-4150

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• Robert H. Michell,

  Roles Conceptualization, Writing – review & editing

  Affiliation School of Biosciences, University of Birmingham, Edgbaston, Birmingham, United Kingdom

  http://orcid.org/0000-0001-9422-9858

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• Roger Meier,

  Roles Investigation, Methodology

  Current address: Scientific Center for Optical and Electron Microscopy, ETH Zürich, Zürich, Switzerland

  Affiliation Institute of Molecular Life Sciences, University of Zürich, Zürich, Switzerland

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• Hubert Hilbi,

  Roles Conceptualization, Funding acquisition, Methodology, Supervision, Writing – review & editing

  Affiliation Institute of Medical Microbiology, University of Zürich, Zürich, Switzerland

  http://orcid.org/0000-0002-5462-9301

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• Thierry Soldati,

  Roles Conceptualization, Methodology, Project administration, Resources, Supervision, Writing – review & editing

  Affiliation Department of Biochemistry, Faculty of Sciences, University of Geneva, Geneva, Switzerland

  http://orcid.org/0000-0002-2056-7931

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• Robert H. Insall ,

  Roles Conceptualization, Funding acquisition, Methodology, Resources, Supervision, Writing – review & editing

  * E-mail: R.Insall@beatson.gla.ac.uk (RHI); Jason.King@sheffield.ac.uk (JSK)

  Affiliation CRUK Beatson Institute, Switchback Road, Bearsden, Glasgow, United Kingdom

  http://orcid.org/0000-0003-4898-040X

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• Jason S. King

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Writing – original draft, Writing – review & editing

  * E-mail: R.Insall@beatson.gla.ac.uk (RHI); Jason.King@sheffield.ac.uk (JSK)

  Affiliations Centre for Membrane Interactions and Dynamics, Department of Biomedical Sciences, University of Sheffield, Firth Court, Western Bank, Sheffield, United Kingdom, Bateson Centre, University of Sheffield, Firth Court, Western Bank, Sheffield, United Kingdom

  http://orcid.org/0000-0003-0596-4506

  ⨯