GPI-anchor signal sequence influences PrP^C sorting, shedding and signalling, and impacts on different pathomechanistic aspects of prion disease in mice

• Berta Puig ,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: b.puig-martorell@uke.de (BP); m.glatzel@uke.de (MG)

  Affiliations Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, Department of Neurology, Experimental Research in Stroke and Inflammation (ERSI), University Medical Center Hamburg-Eppendorf, Hamburg, Germany

  http://orcid.org/0000-0002-2255-8393

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• Hermann C. Altmeppen,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

  http://orcid.org/0000-0001-9439-6533

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• Luise Linsenmeier,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliation Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

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• Karima Chakroun,

  Roles Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliation Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

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• Florian Wegwitz,

  Roles Formal analysis, Investigation, Writing – review & editing

  Affiliation Department of General, Visceral and Pediatric Surgery, Göttingen Center for Molecular Biosciences, University Medical Center Göttingen, Götingen, Germany

  http://orcid.org/0000-0003-0750-6998

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• Ulrike K. Piontek,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliation Adolf Butenandt Institute, Neurobiochemistry, Ludwig Maximilians University Munich, Munich, Germany

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• Jörg Tatzelt,

  Roles Conceptualization, Investigation, Writing – review & editing

  Affiliations Adolf Butenandt Institute, Neurobiochemistry, Ludwig Maximilians University Munich, Munich, Germany, Institute of Biochemistry and Pathobiochemistry, Biochemistry of Neurodegenerative Diseases, Ruhr University Bochum, Bochum, Germany

  http://orcid.org/0000-0001-5017-5528

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• Clive Bate,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliation Department of Pathology and Pathogen Biology, Royal Veterinary College, Hawkshead Lane, North Mymms, Herts, United Kingdom

  http://orcid.org/0000-0002-1378-0005

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• Tim Magnus,

  Roles Conceptualization, Writing – review & editing

  Affiliation Department of Neurology, Experimental Research in Stroke and Inflammation (ERSI), University Medical Center Hamburg-Eppendorf, Hamburg, Germany

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• Markus Glatzel

  Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: b.puig-martorell@uke.de (BP); m.glatzel@uke.de (MG)

  Affiliation Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

  http://orcid.org/0000-0002-7720-8817

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