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Open Access
Peer-reviewed
Research Article
The deubiquitinase CYLD is a specific checkpoint of the STING antiviral signaling pathway
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Lele Zhang ,
Contributed equally to this work with: Lele Zhang, Ning Wei
Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Resources, Software, Validation, Visualization, Writing – original draft, Writing – review & editing
Affiliation State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China
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Ning Wei ,
Contributed equally to this work with: Lele Zhang, Ning Wei
Roles Investigation, Methodology, Resources, Software, Visualization
Affiliation State Key Laboratory of Natural Medicines, School of Life Science and Technology, China Pharmaceutical University, 639 Longmian Avenue, Jiangning District, Nanjing, China
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Ye Cui,
Roles Investigation, Methodology, Writing – review & editing
Affiliation State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China
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Ze Hong,
Roles Resources, Writing – review & editing
Affiliation State Key Laboratory of Natural Medicines, School of Life Science and Technology, China Pharmaceutical University, 639 Longmian Avenue, Jiangning District, Nanjing, China
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Xing Liu,
Roles Methodology, Supervision, Writing – original draft, Writing – review & editing
Affiliation Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China
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Qiang Wang,
Roles Methodology, Resources
Affiliation State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China
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Senlin Li,
Roles Methodology, Resources
Affiliation State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China
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Heng Liu,
Roles Methodology, Resources
Affiliation State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China
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Huansha Yu,
Roles Resources
Affiliation State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China
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Yanni Cai,
Roles Resources
Affiliation State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China
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Quanyi Wang,
Roles Resources
Affiliation State Key Laboratory of Natural Medicines, School of Life Science and Technology, China Pharmaceutical University, 639 Longmian Avenue, Jiangning District, Nanjing, China
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Juanjuan Zhu,
Roles Resources
Affiliation State Key Laboratory of Natural Medicines, School of Life Science and Technology, China Pharmaceutical University, 639 Longmian Avenue, Jiangning District, Nanjing, China
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Wei Meng,
Roles Resources
Affiliation State Key Laboratory of Natural Medicines, School of Life Science and Technology, China Pharmaceutical University, 639 Longmian Avenue, Jiangning District, Nanjing, China
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Zhengjun Chen ,
Roles Funding acquisition, Supervision, Writing – review & editing
* E-mail: zjchen@sibcb.ac.cn (ZC); cwang1971@cpu.edu.cn (CW)
Affiliations State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China, School of Life Science and Technology, Shanghai Tech University, Shanghai, China
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Chen Wang
Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing
* E-mail: zjchen@sibcb.ac.cn (ZC); cwang1971@cpu.edu.cn (CW)
Affiliation State Key Laboratory of Natural Medicines, School of Life Science and Technology, China Pharmaceutical University, 639 Longmian Avenue, Jiangning District, Nanjing, China
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The deubiquitinase CYLD is a specific checkpoint of the STING antiviral signaling pathway
- Lele Zhang,
- Ning Wei,
- Ye Cui,
- Ze Hong,
- Xing Liu,
- Qiang Wang,
- Senlin Li,
- Heng Liu,
- Huansha Yu,
- Yanni Cai
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- Published: November 2, 2018
- https://doi.org/10.1371/journal.ppat.1007435