Delayed oseltamivir plus sirolimus treatment attenuates H1N1 virus-induced severe lung injury correlated with repressed NLRP3 inflammasome activation and inflammatory cell infiltration

• Xuehong Jia ,

  Contributed equally to this work with: Xuehong Jia, Bo Liu

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Project administration, Writing – original draft

  Affiliation Peking University China-Japan Friendship School of Clinical Medicine, Beijing, China; China-Japan Friendship Hospital, Capital Medical University, Beijing, China

  http://orcid.org/0000-0001-7420-9024

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• Bo Liu ,

  Contributed equally to this work with: Xuehong Jia, Bo Liu

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Project administration, Writing – original draft

  Affiliation Department of Pulmonary and Critical Care Medicine, Department of Clinical Microbiology, Zibo City Key Laboratory of Respiratory Infection and Clinical Microbiology, Linzi District People’s Hospital, Zibo, Shandong, China

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• Linlin Bao ,

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Writing – original draft

  ¶‡ LB also contributed equally to this work.

  Affiliation Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences (CAMS) and Comparative Medicine Center, Peking Union Medical College (PUMC), Key Laboratory of Human Disease Comparative Medicine, Ministry of Health, Beijing, China

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• Qi Lv,

  Roles Conceptualization, Formal analysis, Investigation, Methodology

  Affiliation Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences (CAMS) and Comparative Medicine Center, Peking Union Medical College (PUMC), Key Laboratory of Human Disease Comparative Medicine, Ministry of Health, Beijing, China

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• Fengdi Li,

  Roles Conceptualization, Investigation, Methodology

  Affiliation Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences (CAMS) and Comparative Medicine Center, Peking Union Medical College (PUMC), Key Laboratory of Human Disease Comparative Medicine, Ministry of Health, Beijing, China

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• Hui Li,

  Roles Conceptualization, Formal analysis, Project administration

  Affiliation Department of Pulmonary and Critical Care Medicine, Center for Respiratory Diseases, China-Japan Friendship Hospital, Beijing, China

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• Yunqing An,

  Roles Conceptualization, Methodology, Project administration

  Affiliation Department of Immunology, School of Basic Medical Sciences, Capital Medical University, Beijing, China

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• Xulong Zhang ,

  Roles Conceptualization, Formal analysis, Funding acquisition, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: zhxlwl@ccmu.edu.cn (XZ); caobin_ben@163.com (BC); cyh-birm@263.net (CW)

  Affiliation Department of Immunology, School of Basic Medical Sciences, Capital Medical University, Beijing, China

  http://orcid.org/0000-0002-9488-0306

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• Bin Cao ,

  Roles Conceptualization, Formal analysis, Funding acquisition, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: zhxlwl@ccmu.edu.cn (XZ); caobin_ben@163.com (BC); cyh-birm@263.net (CW)

  Affiliations Department of Pulmonary and Critical Care Medicine, Center for Respiratory Diseases, China-Japan Friendship Hospital, Beijing, China, Clinical Center for Pulmonary Infections, Capital Medical University, Beijing, China, National Clinical Research Center for Respiratory Diseases, Beijing, China, Tsinghua University-Peking University Joint Center for Life Sciences, Beijing, China

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• Chen Wang

  Roles Conceptualization, Formal analysis, Project administration, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: zhxlwl@ccmu.edu.cn (XZ); caobin_ben@163.com (BC); cyh-birm@263.net (CW)

  Affiliations Peking University China-Japan Friendship School of Clinical Medicine, Beijing, China; China-Japan Friendship Hospital, Capital Medical University, Beijing, China, Department of Pulmonary and Critical Care Medicine, Center for Respiratory Diseases, China-Japan Friendship Hospital, Beijing, China, Clinical Center for Pulmonary Infections, Capital Medical University, Beijing, China, National Clinical Research Center for Respiratory Diseases, Beijing, China, Tsinghua University-Peking University Joint Center for Life Sciences, Beijing, China, Chinese Academy of Medical Sciences (CAMS), Peking Union Medical College (PUMC), Beijing, China, Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Beijing, China

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