IgA tetramerization improves target breadth but not peak potency of functionality of anti-influenza virus broadly neutralizing antibody

• Shinji Saito ,

  Contributed equally to this work with: Shinji Saito, Kaori Sano

  Roles Conceptualization, Investigation, Methodology, Resources, Writing – original draft

  Affiliations Department of Pathology, National Institute of Infectious Diseases, Shinjuku, Tokyo, Japan, Influenza Virus Research Center, National Institute of Infectious Diseases, Musashimurayama, Tokyo, Japan

  ⨯
• Kaori Sano ,

  Contributed equally to this work with: Shinji Saito, Kaori Sano

  Roles Conceptualization, Investigation, Methodology, Resources, Writing – original draft, Writing – review & editing

  Affiliations Department of Pathology, National Institute of Infectious Diseases, Shinjuku, Tokyo, Japan, Division of Infectious Diseases Pathology, Department of Global Infectious Diseases, Tohoku Graduate School of Medicine, Sendai, Miyagi, Japan

  ⨯
• Tadaki Suzuki ,

  Roles Conceptualization, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: tksuzuki@nih.go.jp (TS); hasegawa@nih.go.jp (HH)

  Affiliation Department of Pathology, National Institute of Infectious Diseases, Shinjuku, Tokyo, Japan

  http://orcid.org/0000-0002-3820-9542

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• Akira Ainai,

  Roles Investigation, Methodology, Resources

  Affiliation Department of Pathology, National Institute of Infectious Diseases, Shinjuku, Tokyo, Japan

  ⨯
• Yuki Taga,

  Roles Investigation, Methodology

  Affiliation Nippi Research Institute of Biomatrix, Toride, Ibaraki, Japan

  http://orcid.org/0000-0001-9100-758X

  ⨯
• Tomonori Ueno,

  Roles Investigation

  Affiliation Nippi Research Institute of Biomatrix, Toride, Ibaraki, Japan

  ⨯
• Koshiro Tabata,

  Roles Investigation

  Affiliation Department of Pathology, National Institute of Infectious Diseases, Shinjuku, Tokyo, Japan

  ⨯
• Kumpei Saito,

  Roles Investigation, Resources

  Affiliation Department of Pathology, National Institute of Infectious Diseases, Shinjuku, Tokyo, Japan

  ⨯
• Yuji Wada,

  Roles Investigation, Resources

  Affiliation Department of Pathology, National Institute of Infectious Diseases, Shinjuku, Tokyo, Japan

  ⨯
• Yuki Ohara,

  Roles Investigation

  Affiliation Department of Pathology, National Institute of Infectious Diseases, Shinjuku, Tokyo, Japan

  ⨯
• Haruko Takeyama,

  Roles Supervision, Validation

  Affiliation Department of Life Science and Medical Bioscience, Waseda University, Shinjuku, Tokyo, Japan

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• Takato Odagiri,

  Roles Resources

  Affiliation Influenza Virus Research Center, National Institute of Infectious Diseases, Musashimurayama, Tokyo, Japan

  ⨯
• Tsutomu Kageyama,

  Roles Resources

  Affiliation Influenza Virus Research Center, National Institute of Infectious Diseases, Musashimurayama, Tokyo, Japan

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• Kiyoko Ogawa-Goto,

  Roles Investigation, Methodology

  Affiliation Nippi Research Institute of Biomatrix, Toride, Ibaraki, Japan

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• Pretty Multihartina,

  Roles Resources

  Affiliation National Institute of Health Research and Development, Ministry of Health RI, Jakarta, Indonesia

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• Vivi Setiawaty,

  Roles Resources

  Affiliation National Institute of Health Research and Development, Ministry of Health RI, Jakarta, Indonesia

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• Krisna Nur Andriana Pangesti,

  Roles Resources

  Affiliation National Institute of Health Research and Development, Ministry of Health RI, Jakarta, Indonesia

  http://orcid.org/0000-0001-6339-915X

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•  [ ... ],
• Hideki Hasegawa

  Roles Funding acquisition, Project administration, Supervision, Writing – review & editing

  * E-mail: tksuzuki@nih.go.jp (TS); hasegawa@nih.go.jp (HH)

  Affiliations Department of Pathology, National Institute of Infectious Diseases, Shinjuku, Tokyo, Japan, Division of Infectious Diseases Pathology, Department of Global Infectious Diseases, Tohoku Graduate School of Medicine, Sendai, Miyagi, Japan

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